7W3Q
Crystal structure of RORgamma in complex with natural inverse agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 246 | 28639.2 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (C) | Peptide from Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-6-methyl-2-oxidanyl-hept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol | non-polymer | 476.7 | 1 | Chemie (97I) PubChem (22392424) PubChem (24996147) PubChem (44198762) PubChem (51066493) PubChem (58590073) PubChem (58590075) PubChem (59067011) PubChem (60007750) PubChem (60007753) PubChem (56845272) PubChem (68586777) PubChem (68586778) PubChem (5320744) PubChem (176520001) PubChem (161798) PubChem (9847854) PubChem (91562468) PubChem (91884761) PubChem (11468733) PubChem (101157055) PubChem (122130481) PubChem (124917917) PubChem (124917915) PubChem (124917918) PubChem (9847853) PubChem (118718679) PubChem (118718705) PubChem (124910502) PubChem (124910504) PubChem (124910506) PubChem (124910507) PubChem (124917916) PubChem (125463125) PubChem (129607061) PubChem (131676237) PubChem (146157239) PubChem (134694152) PubChem (163199257) PubChem (138114286) PubChem (138548919) PubChem (145163393) PubChem (171363703) PubChem (156489346) PubChem (162896520) PubChem (162896521) PubChem (162896522) PubChem (162896523) PubChem (162896524) PubChem (162896525) PubChem (168314320) PubChem (170924525) PubChem (171363599) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30219.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 476.7 | |
| All* | Total formula weight | 30695.8 |
