7W3L
Crystal structure of LSD1 in complex with cis-4-Br-2,5-F2-PCPA (S1024)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Lysine-specific histone demethylase 1A | polymer | 669 | 74333.0 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) In PDB | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 3 | A | 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal | non-polymer | 249.1 | 1 | Chemie (8A2) | |||
| 4 | A | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 172 - 833 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Gly 165 | - | expression tag |
| Pro 166 | - | expression tag |
| Leu 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Ser 169 | - | expression tag |
| His 170 | - | expression tag |
| Met 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 74333.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1737.3 | |
| All* | Total formula weight | 76070.3 |
