7W3I
Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | x | Ubiquitin carboxyl-terminal hydrolase 14 | polymer | 494 | 56133.9 | 1 | UniProt (P54578) Pfam (PF00443) In PDB | Homo sapiens (human) | Deubiquitinating enzyme 14,Ubiquitin thioesterase 14,Ubiquitin-specific-processing protease 14 |
| 2 | A | 26S protease regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) Pfam (PF21236) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1 |
| 3 | B | 26S protease regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 4 | C | Isoform 2 of 26S proteasome regulatory subunit 8 | polymer | 398 | 44852.1 | 1 | UniProt (P62195) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG |
| 5 | D | 26S protease regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 6 | E | 26S proteasome regulatory subunit 10B | polymer | 403 | 45867.0 | 1 | UniProt (A0A087X2I1) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | |
| 7 | F | 26S protease regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) In PDB | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 8 | G, g | Proteasome subunit alpha type-6 | polymer | 246 | 27432.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | 27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 9 | H, h | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 10 | I, i | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 11 | J, j | Proteasome subunit alpha type-7 | polymer | 248 | 27929.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 12 | K, k | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 13 | L, l | Isoform Long of Proteasome subunit alpha type-1 | polymer | 269 | 30281.5 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 14 | M, m | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 15 | N, n | Proteasome subunit beta type-6 | polymer | 239 | 25377.7 | 2 | UniProt (P28072) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y |
| 16 | O, o | Proteasome subunit beta type-7 | polymer | 277 | 30000.4 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) In PDB | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 17 | P, p | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) In PDB | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 18 | Q, q | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 19 | R, r | Proteasome subunit beta type-5 | polymer | 263 | 28510.2 | 2 | UniProt (P28074) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 20 | S, s | Proteasome subunit beta type-1 | polymer | 241 | 26522.4 | 2 | UniProt (P20618) Pfam (PF00227) In PDB | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 21 | T, t | Proteasome subunit beta type-4 | polymer | 264 | 29231.2 | 2 | UniProt (P28070) Pfam (PF00227) In PDB | Homo sapiens (human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 22 | y | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) In PDB | Homo sapiens (human) | |
| 23 | U | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 953 | 105958.2 | 1 | UniProt (Q99460) Pfam (PF21505) Pfam (PF01851) Pfam (PF13646) Pfam (PF18004) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112 |
| 24 | V | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 534 | 61066.5 | 1 | UniProt (O43242) Pfam (PF01399) Pfam (PF08375) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58 |
| 25 | W | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) Pfam (PF01399) Pfam (PF18098) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55 |
| 26 | X | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 422 | 47526.7 | 1 | UniProt (O00231) Pfam (PF18055) Pfam (PF01399) Pfam (PF18503) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5 |
| 27 | Y | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 389 | 45592.3 | 1 | UniProt (Q15008) Pfam (PF10602) Pfam (PF01399) Pfam (PF21154) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A |
| 28 | Z | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 324 | 37086.4 | 1 | UniProt (P51665) Pfam (PF01398) Pfam (PF13012) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 29 | a | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 376 | 42995.4 | 1 | UniProt (Q9UNM6) Pfam (PF01399) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5 |
| 30 | b | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 377 | 40781.6 | 1 | UniProt (P55036) Pfam (PF13519) Pfam (PF02809) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,ASF,Multiubiquitin chain-binding protein |
| 31 | c | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 310 | 34620.0 | 1 | UniProt (O00487) Pfam (PF01398) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1 |
| 32 | d | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 350 | 39667.9 | 1 | UniProt (P48556) Pfam (PF10075) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31 |
| 33 | f | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) Pfam (PF17781) Pfam (PF01851) Pfam (PF18051) In PDB | Homo sapiens (human) | 26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2 |
| 34 | e | 26S proteasome complex subunit DSS1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) Pfam (PF05160) In PDB | Homo sapiens (human) | Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 35 | E, F, A, D | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 36 | B, C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 37 | c | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 48 |
| Total formula weight | 1729919.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2948.5 | |
| All* | Total formula weight | 1732867.9 |
