7W2K
Deactive state CI from Rotenone-NADH dataset, Subclass 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 431 | 47265.9 | 1 | UniProt (F1RVN1) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) UniProt (by SIFTS) (A0A4X1SZP7) | Sus scrofa (pig) | |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20208.0 | 1 | UniProt (A0A287BDC0) Pfam (PF12838) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 23 kDa subunit,Complex I-23kD |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17875.0 | 1 | UniProt (I3LK43) Pfam (PF01058) UniProt (by SIFTS) (A0A8D1TL60) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 20 kDa subunit,Complex I-20kD |
| 4 | D (E) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 115 | 13813.0 | 1 | UniProt (A0A480VKQ8) Pfam (PF05347) UniProt (by SIFTS) (F1SJP6) | Sus scrofa (pig) | |
| 5 | E (F) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 86 | 9841.3 | 1 | UniProt (F1RGE3) Pfam (PF05047) | Sus scrofa (pig) | |
| 6 | F, V (G, X) | Acyl carrier protein | polymer | 88 | 10133.6 | 2 | UniProt (D0G781) Pfam (PF00550) UniProt (by SIFTS) (A0A287AAR5) | Sus scrofa (pig) | |
| 7 | G (H) | Complex I subunit B13 | polymer | 112 | 12949.1 | 1 | UniProt (A0A5G2RN85) Pfam (PF04716) UniProt (by SIFTS) (A0A287BAW0) | Sus scrofa (pig) | Complex I-13kD-B,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 8 | H (I) | Complex I-B14.5a | polymer | 112 | 12517.4 | 1 | UniProt (A0A4X1VLA2) Pfam (PF07347) UniProt (by SIFTS) (A0A8W4F7N8) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 9 | I (J) | NADH:ubiquinone oxidoreductase subunit A9 | polymer | 342 | 38940.0 | 1 | UniProt (F1SL07) Pfam (PF01370) | Sus scrofa (pig) | |
| 10 | J (K) | Complex I-9kD | polymer | 42 | 5046.5 | 1 | UniProt (A0A4X1TFI3) Pfam (PF15880) UniProt (by SIFTS) (I3LRR4) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] flavoprotein 3,mitochondrial,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 11 | K (L) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 125 | 14442.4 | 1 | UniProt (G8IFA6) | Sus scrofa (pig) | Complex I-18 kDa,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 12 | L (M) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 690 | 75770.8 | 1 | UniProt (F1SHD7) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) UniProt (by SIFTS) (A0A4X1V1H9) | Sus scrofa (pig) | |
| 13 | M (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 144 | 17031.2 | 1 | UniProt (F1SQP4) Pfam (PF05071) | Sus scrofa (pig) | |
| 14 | N (O) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 217 | 23826.3 | 1 | UniProt (A0A287BG40) Pfam (PF01257) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 15 | O (P) | Complex I-30kD | polymer | 208 | 24521.7 | 1 | UniProt (A0A286ZNN4) Pfam (PF00329) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3,mitochondrial,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 16 | P (Q) | Complex I-49kD | polymer | 430 | 49234.3 | 1 | UniProt (A0A480JYS1) Pfam (PF00346) UniProt (by SIFTS) (F1S1A8) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2,mitochondrial,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 17 | Q (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8088.4 | 1 | UniProt (K7GR43) Pfam (PF15879) | Sus scrofa (pig) | |
| 18 | R (T) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 96 | 10567.6 | 1 | UniProt (F1S031) Pfam (PF10276) | Sus scrofa (pig) | |
| 19 | S (U) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 83 | 9094.4 | 1 | UniProt (A0A4X1VQ42) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B9 subunit,Complex I-B9 |
| 20 | T (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14555.7 | 1 | UniProt (I3LGM4) Pfam (PF02466) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase subunit B14.7,Complex I-B14.7 |
| 21 | U (W) | Complex I-B16.6 | polymer | 142 | 16709.3 | 1 | UniProt (F1S6Q1) Pfam (PF06212) UniProt (by SIFTS) (A0A8D1NRT6) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 22 | W (Y) | Complex I-AGGG | polymer | 70 | 8430.3 | 1 | UniProt (A0A4X1V766) Pfam (PF14813) UniProt (by SIFTS) (A0A5G2QW32) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2,mitochondrial,NADH-ubiquinone oxidoreductase AGGG subunit |
| 23 | X (Z) | Complex I-B12 | polymer | 84 | 9504.7 | 1 | UniProt (A0A287AS93) Pfam (PF08122) UniProt (by SIFTS) (A0A4X1VD84) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3,NADH-ubiquinone oxidoreductase B12 subunit |
| 24 | Y (a) | Complex I-SGDH | polymer | 140 | 16477.1 | 1 | UniProt (F1SGC6) Pfam (PF09781) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5,mitochondrial,NADH-ubiquinone oxidoreductase SGDH subunit |
| 25 | Z (b) | Complex I-B17 | polymer | 126 | 15333.8 | 1 | UniProt (Q2EN80) Pfam (PF09782) UniProt (by SIFTS) (A0A480KM09) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH-ubiquinone oxidoreductase B17 subunit |
| 26 | AA (c) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 156 | 18608.8 | 1 | UniProt (F1RWL7) Pfam (PF05821) | Sus scrofa (pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 27 | BA (d) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 175 | 20813.6 | 1 | UniProt (A0A4X1VYV0) UniProt (by SIFTS) (A0A8D0R7A9) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW |
| 28 | CA (e) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 107 | 12635.1 | 1 | UniProt (A0A8D1EYI7) | Sus scrofa (pig) | Complex I-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 29 | DA (f) | Complex I-KFYI | polymer | 42 | 4945.7 | 1 | UniProt (A1XQS6) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 subunit C1,mitochondrial,NADH-ubiquinone oxidoreductase KFYI subunit |
| 30 | EA (g) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 121 | 14196.5 | 1 | UniProt (A0A480JRW3) Pfam (PF06374) | Sus scrofa (pig) | |
| 31 | FA (h) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12375.4 | 1 | UniProt (F1SV23) Pfam (PF10200) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 15 kDa subunit,Complex I-15 kDa |
| 32 | GA (i) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) Pfam (PF00361) Pfam (PF06444) | Sus scrofa (pig) | NADH dehydrogenase subunit 2 |
| 33 | HA (j) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 113 | 12798.3 | 1 | UniProt (O79880) Pfam (PF00507) | Sus scrofa (pig) | NADH dehydrogenase subunit 3 |
| 34 | IA (k) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) Pfam (PF00420) | Sus scrofa (pig) | NADH dehydrogenase subunit 4L |
| 35 | JA (l) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 603 | 68267.0 | 1 | UniProt (Q71K68) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) UniProt (by SIFTS) (Q9TDR1) | Sus scrofa (pig) | |
| 36 | KA (m) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19021.3 | 1 | UniProt (O79882) Pfam (PF00499) | Sus scrofa (pig) | NADH dehydrogenase subunit 6 |
| 37 | LA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 56 | 6781.9 | 1 | UniProt (F1SD73) Pfam (PF08040) UniProt (by SIFTS) (A0A8D2CGH8) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase MNLL subunit,Complex I-MNLL |
| 38 | MA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 14986.2 | 1 | UniProt (A0A4X1T6M0) Pfam (PF07225) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15 |
| 39 | NA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 178 | 21733.7 | 1 | UniProt (A0A4X1T0A8) Pfam (PF05347) UniProt (by SIFTS) (K7GSE5) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B22 subunit,Complex I-B22 |
| 40 | OA (r) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51853.4 | 1 | UniProt (Q7IIB7) Pfam (PF01059) Pfam (PF00361) UniProt (by SIFTS) (O79881) | Sus scrofa (pig) | |
| 41 | PA (s) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) Pfam (PF00146) | Sus scrofa (pig) | NADH dehydrogenase subunit 1 |
| 42 | QA (u) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 19932.9 | 1 | UniProt (F1SLR1) Pfam (PF06747) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD |
| 43 | RA (v) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 131 | 15785.1 | 1 | UniProt (F1SCH1) Pfam (PF05676) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B18 subunit,Complex I-B18 |
| 44 | SA (w) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 36792.7 | 1 | UniProt (F1SIS9) Pfam (PF01712) | Sus scrofa (pig) | |
| 45 | EB, FB, TA, WA, XA... (M, A, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 46 | UA (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (23585816) PubChem (8965) PubChem (51435500) PubChem (51435503) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 47 | VA (A) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 48 | AB, AC, JB, OB, SB... (C, s, Q, b, j...) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 8 | Chemie (PEE) PubChem (108229) PubChem (44891344) PubChem (54095275) PubChem (14238554) PubChem (5909904) PubChem (9546757) PubChem (6437392) PubChem (99655478) PubChem (99655479) PubChem (9546744) PubChem (138113035) PubChem (171729549) | |||
| 49 | BB, NB, PB, QB, TB... (C, a, e, g, j...) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 6 | Chemie (PLX) PubChem (49867511) | |||
| 50 | CB, LB (G, X) | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate | non-polymer | 540.7 | 2 | Chemie (8Q1) PubChem (119058169) PubChem (122362359) PubChem (162826280) | |||
| 51 | DB (J) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 52 | GB, IB (M, O) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 53 | HB (M) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 54 | KB (T) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 55 | CC, MB, RB, UB, VB... (u, a, i, l, r) | CARDIOLIPIN | non-polymer | 1464.0 | 6 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 56 | BC (s) | Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer | non-polymer | 863.3 | 1 | Chemie (UQ) PubChem (17572160) PubChem (45266508) PubChem (1156) PubChem (5281915) PubChem (5366029) PubChem (5354031) PubChem (6473741) PubChem (5926222) PubChem (97038292) PubChem (97038293) PubChem (6857782) PubChem (9811994) PubChem (12303768) PubChem (12303769) PubChem (124919119) PubChem (124919120) PubChem (131954658) PubChem (137350098) | |||
| 57 | DC (w) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
J: 36 - 377 (UniProt: F1SL07)
v: 2 - 131 (UniProt: F1SCH1)
| PDB | External Database | Details |
|---|---|---|
| Val 377 | Ile 372 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Myr 1 | - | acetylation |
| Ala 126 | Gln 126 | conflict |
| Ala 128 | Pro 128 | conflict |
| Ala 130 | Glu 130 | conflict |
| Ala 131 | Val 131 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 949411.1 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 26129.6 | |
| All* | Total formula weight | 975540.6 |
