7W1A
Crystal Structure of MPH-E in complex with GMP and Azithromycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Macrolide 2'-phosphotransferase | polymer | 302 | 34619.6 | 2 | UniProt (A5Y459) | Acinetobacter baumannii | Macrolide 2'-phosphotransferase,Mph(E)/Mph(G) family,Mph(E) family macrolide 2'-phosphotransferase,Mph(E) macrolide 2'-phosphotransferase,Mph2,Putative aminoglycoside phosphotransferase |
| 2 | C, E (B, A) | GUANOSINE | non-polymer | 283.2 | 2 | Chemie (GMP) PubChem (135499520) PubChem (162360751) PubChem (135398635) PubChem (135402034) PubChem (135426840) PubChem (135440077) PubChem (135484501) PubChem (135508725) PubChem (135514572) PubChem (135538738) PubChem (135546397) PubChem (135699331) PubChem (135726185) PubChem (135768161) PubChem (135768162) PubChem (135796591) PubChem (135823787) PubChem (135976484) PubChem (136019960) PubChem (136029099) PubChem (136029343) PubChem (136032217) PubChem (136073062) PubChem (136073540) PubChem (136168113) PubChem (136200123) PubChem (136259572) PubChem (136263240) PubChem (136461600) PubChem (136474462) PubChem (136490162) PubChem (136594098) PubChem (136596777) PubChem (136612256) PubChem (136614128) PubChem (136835877) PubChem (136912867) PubChem (136996824) PubChem (137506101) PubChem (163824507) PubChem (166857379) PubChem (168265885) PubChem (173984522) | |||
| 3 | D, F (B, A) | AZITHROMYCIN | non-polymer | 749.0 | 2 | Chemie (ZIT) PubChem (2269) PubChem (447043) PubChem (71120102) PubChem (10771356) PubChem (11029030) PubChem (16757819) PubChem (20056474) PubChem (71190996) PubChem (23304247) PubChem (71191184) PubChem (25235496) PubChem (176529195) PubChem (45357541) PubChem (177594943) PubChem (16413916) PubChem (21733141) PubChem (23229892) PubChem (22869773) PubChem (44452787) PubChem (44317861) PubChem (71206930) PubChem (44661448) PubChem (45482397) PubChem (71206984) PubChem (49849544) PubChem (56845505) PubChem (57149533) PubChem (57765354) PubChem (58652532) PubChem (58756473) PubChem (58668032) PubChem (58846526) PubChem (58846527) PubChem (59022407) PubChem (59075891) PubChem (59771745) PubChem (59985602) PubChem (60052040) PubChem (71211241) PubChem (176519926) PubChem (55185) PubChem (70908014) PubChem (71066582) PubChem (73265194) PubChem (51371100) PubChem (456416) PubChem (89802855) PubChem (89969202) PubChem (89970527) PubChem (3086605) PubChem (90489754) PubChem (90927984) PubChem (90989076) PubChem (53477736) PubChem (6324605) PubChem (124604982) PubChem (124821849) PubChem (124761724) PubChem (124761726) PubChem (125180820) PubChem (126603997) PubChem (126969870) PubChem (129255978) PubChem (129313115) PubChem (129264255) PubChem (129396765) PubChem (129428544) PubChem (129830452) PubChem (10952758) PubChem (131887698) PubChem (11104628) PubChem (133109198) PubChem (133588153) PubChem (133556211) PubChem (11969951) PubChem (57793951) PubChem (138105984) PubChem (13326587) PubChem (140919655) PubChem (58593561) PubChem (58613197) PubChem (58647134) PubChem (58649002) PubChem (145948753) PubChem (58816759) PubChem (148533668) PubChem (154825141) PubChem (58984289) PubChem (156588285) PubChem (159644379) PubChem (166639262) PubChem (166666711) PubChem (168138115) PubChem (171114714) PubChem (171114697) PubChem (171360714) PubChem (173722062) PubChem (176093648) PubChem (59856260) PubChem (59910644) PubChem (59982920) PubChem (60054509) PubChem (60086514) PubChem (71094687) PubChem (91466261) PubChem (91486800) PubChem (124721102) PubChem (124721103) PubChem (124721104) PubChem (124721105) PubChem (124761720) PubChem (124761721) PubChem (124761722) PubChem (124761723) PubChem (124761725) PubChem (124761727) PubChem (124821850) PubChem (124821851) PubChem (124821852) PubChem (124894582) PubChem (124894583) PubChem (124894584) PubChem (129009944) PubChem (129010025) PubChem (129010374) PubChem (129428530) PubChem (129428531) PubChem (129428532) PubChem (129627814) PubChem (131845181) PubChem (132199928) PubChem (132274083) PubChem (133562860) PubChem (134693946) PubChem (134693958) PubChem (134750426) PubChem (137704936) PubChem (142181598) PubChem (156853354) PubChem (157454801) PubChem (159644380) PubChem (159644381) PubChem (159644382) PubChem (171156713) PubChem (175970442) | |||
| 4 | G, H (B, A) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 294 (UniProt: A5Y459)
| PDB | External Database | Details |
|---|---|---|
| Leu 295 | - | expression tag |
| Glu 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
| His 302 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69239.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2064.4 | |
| All* | Total formula weight | 71303.6 |
