7W1A

Crystal Structure of MPH-E in complex with GMP and Azithromycin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Macrolide 2'-phosphotransferase	polymer	302	34619.6	2	UniProt (A5Y459) Pfam (PF01636) In PDB	Acinetobacter baumannii	Macrolide 2'-phosphotransferase,Mph(E)/Mph(G) family,Mph(E) family macrolide 2'-phosphotransferase,Mph(E) macrolide 2'-phosphotransferase,Mph2,Putative aminoglycoside phosphotransferase
2	B, A	GUANOSINE	non-polymer		283.2	2	Chemie (GMP)
3	B, A	AZITHROMYCIN	non-polymer		749.0	2	Chemie (ZIT)
4		water	water		18.0	69	Chemie (HOH)

Sequence modifications

B, A: 1 - 294 (UniProt: A5Y459)

PDB	External Database	Details
Leu 295	-	expression tag
Glu 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag
His 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69239.2
Non-Polymers*	Number of molecules	4
	Total formula weight	2064.4
All*	Total formula weight	71303.6

*Water molecules are not included.