7VVD

Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, D)	Potassium voltage-gated channel subfamily KQT member 1,Potassium voltage-gated channel subfamily KQT member 1	polymer	69	8122.4	2	UniProt (P51787)	Homo sapiens (Human)	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1,IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1
2	B, D (C, E)	Calmodulin-1	polymer	149	16821.5	2	UniProt (P0DP23) Pfam (PF13499)	Homo sapiens (Human)
3	E, F, G, H (C, E)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
4	I, J (C, E)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, D: 364 - 397 (UniProt: P51787)
A, D: 503 - 533 (UniProt: P51787)

PDB	External Database	Details
Ile 534	-	expression tag
Gly 535	-	expression tag
Ser 536	-	expression tag
Gly 537	-	expression tag

C, E: 0 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Pro 135	Gln 136	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	49887.9
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	50048.2

*Water molecules are not included.