7VTP
Cryo-EM structure of PYD-deleted human NLRP3 hexamer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | NACHT, LRR and PYD domains-containing protein 3 | polymer | 931 | 106298.5 | 6 | UniProt (Q96P20) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516) In PDB | Homo sapiens (Human) | |
2 | A, B, C, D, E... | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
3 | A, B, C, D, E... | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea | non-polymer | 402.5 | 6 | Chemie (7YN) |
Sequence modifications
A, B, C, D, E, F: 130 - 1036 (UniProt: Q96P20)
PDB | External Database | Details |
---|---|---|
His 106 | - | expression tag |
His 107 | - | expression tag |
His 108 | - | expression tag |
His 109 | - | expression tag |
His 110 | - | expression tag |
His 111 | - | expression tag |
Asp 112 | - | expression tag |
Tyr 113 | - | expression tag |
Lys 114 | - | expression tag |
Asp 115 | - | expression tag |
Asp 116 | - | expression tag |
Asp 117 | - | expression tag |
Asp 118 | - | expression tag |
Lys 119 | - | expression tag |
Leu 120 | - | expression tag |
Glu 121 | - | expression tag |
Val 122 | - | expression tag |
Leu 123 | - | expression tag |
Phe 124 | - | expression tag |
Gln 125 | - | expression tag |
Gly 126 | - | expression tag |
Pro 127 | - | expression tag |
Glu 128 | - | expression tag |
Phe 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 637791.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4978.0 | |
All* | Total formula weight | 642769.2 |