7VTP

Cryo-EM structure of PYD-deleted human NLRP3 hexamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NACHT, LRR and PYD domains-containing protein 3	polymer	931	106298.5	6	UniProt (Q96P20) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516)	Homo sapiens (Human)
2	G, I, K, M, O... (A, B, C, D, E...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	6	Chemie (ADP)
3	H, J, L, N, P... (A, B, C, D, E...)	1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea	non-polymer		402.5	6	Chemie (7YN)

Sequence modifications

A, B, C, D, E, F: 130 - 1036 (UniProt: Q96P20)

PDB	External Database	Details
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
His 111	-	expression tag
Asp 112	-	expression tag
Tyr 113	-	expression tag
Lys 114	-	expression tag
Asp 115	-	expression tag
Asp 116	-	expression tag
Asp 117	-	expression tag
Asp 118	-	expression tag
Lys 119	-	expression tag
Leu 120	-	expression tag
Glu 121	-	expression tag
Val 122	-	expression tag
Leu 123	-	expression tag
Phe 124	-	expression tag
Gln 125	-	expression tag
Gly 126	-	expression tag
Pro 127	-	expression tag
Glu 128	-	expression tag
Phe 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	637791.2
Non-Polymers*	Number of molecules	12
	Total formula weight	4978.0
All*	Total formula weight	642769.2

*Water molecules are not included.