7VRI
crystal structure of BRD2-BD2 in complex with guanosine analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 115 | 13440.3 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | B (A) | 9-HYROXYETHOXYMETHYLGUANINE | non-polymer | 225.2 | 1 | Chemie (AC2) | |||
| 3 | C (A) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| His 343 | - | expression tag |
| Met 344 | - | expression tag |
| Gln 345 | - | expression tag |
| Asp 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Ser 358 | Lys 358 | engineered mutation |
| Ser 363 | Lys 363 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13440.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 225.2 | |
| All* | Total formula weight | 13665.5 |
