7VRE
The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 331 | 37460.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine | non-polymer | 658.6 | 1 | Chemie (7VH) | |||
| 3 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ala 693 | - | expression tag |
| Met 694 | - | expression tag |
| Gly 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
| Ala 865 | Glu 865 | conflict |
| Ala 866 | Glu 866 | conflict |
| Ala 867 | Lys 867 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37460.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 658.6 | |
| All* | Total formula weight | 38119.0 |
