7VMV

Crystal structure of Dengue NS2B-NS3 Protease after secondary cleavage

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Core protein	polymer	82	9407.2	4	UniProt (A0A0M4C4I5) Pfam (PF01002) UniProt (by SIFTS) (Q58HT7)	Dengue virus 4	Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M
2	B, D, F, H (B, D, F, H)	Core protein	polymer	181	19621.2	4	UniProt (Q5I3B6) Pfam (PF00949)	Dengue virus 4	Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M

Sequence modifications

A, C, E, G: 48 - 95 (UniProt: A0A0M4C4I5)

PDB	External Database	Details
Met 21	-	initiating methionine
Ser 22	-	expression tag
Tyr 23	-	expression tag
Tyr 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
Asp 31	-	expression tag
Tyr 32	-	expression tag
Asp 33	-	expression tag
Ile 34	-	expression tag
Pro 35	-	expression tag
Thr 36	-	expression tag
Thr 37	-	expression tag
Glu 38	-	expression tag
Asn 39	-	expression tag
Leu 40	-	expression tag
Tyr 41	-	expression tag
Phe 42	-	expression tag
Gln 43	-	expression tag
Gly 44	-	expression tag
Ala 45	-	expression tag
Met 46	-	expression tag
Gly 47	-	expression tag
Ala 96	-	expression tag
Gln 97	-	expression tag
Val 98	-	expression tag
Lys 99	-	expression tag
Thr 100	-	expression tag
Gln 101	-	expression tag
Arg 102	-	expression tag

B, D, F, H: 1 - 181 (UniProt: Q5I3B6)

PDB	External Database	Details
Ala 43	Glu 1513	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	116113.7
All*	Total formula weight	116113.7

*Water molecules are not included.