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Crystal structure of IQSEC1-IQ motif, Sec7PH tandem in complex with calmodulin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
IQ motif and SEC7 domain-containing protein 1polymer37243256.01UniProt (Q6DN90)
Pfam (PF01369)
Pfam (PF16453)
Homo sapiens (Human)ADP-ribosylation factors guanine nucleotide-exchange protein 100,ADP-ribosylation factors guanine nucleotide-exchange protein 2,Brefeldin-resistant Arf-GEF 2 protein,BRAG2
2B
(B)
IQ motif and SEC7 domain-containing protein 1polymer748716.81UniProt (Q6DN90)Homo sapiens (Human)ADP-ribosylation factors guanine nucleotide-exchange protein 100,ADP-ribosylation factors guanine nucleotide-exchange protein 2,Brefeldin-resistant Arf-GEF 2 protein,BRAG2
3C
(C)
Calmodulin-1polymer15317150.81UniProt (P0DP23)
Pfam (PF13499)
Homo sapiens (Human)
4D, E, F
(A)
GLYCEROLnon-polymer92.13Chemie (GOL)
5G, H, I
(A, B, C)
waterwater18.0268Chemie (HOH)
Sequence modifications
A: 517 - 882 (UniProt: Q6DN90)
PDBExternal DatabaseDetails
Gly 511-expression tag
Pro 512-expression tag
Gly 513-expression tag
Ser 514-expression tag
Glu 515-expression tag
Phe 516-expression tag
B: 106 - 173 (UniProt: Q6DN90)
PDBExternal DatabaseDetails
Gly 100-expression tag
Pro 101-expression tag
Gly 102-expression tag
Ser 103-expression tag
Glu 104-expression tag
Phe 105-expression tag
C: 0 - 148 (UniProt: P0DP23)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight69123.7
Non-Polymers*Number of molecules3
Total formula weight276.3
All*Total formula weight69400.0
*Water molecules are not included.

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PDB entries from 2025-07-16

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