7VL9
Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (L) | CCL15(26-92) | polymer | 76 | 8365.7 | 1 | UniProt (Q16663) Pfam (PF00048) | Homo sapiens (Human) | |
| 5 | E (R) | C-C chemokine receptor type 1 | polymer | 365 | 42203.5 | 1 | UniProt (P32246) Pfam (PF00001) | Homo sapiens (Human) | C-C CKR-1,CC-CKR-1,CCR-1,CCR1,HM145,LD78 receptor,Macrophage inflammatory protein 1-alpha receptor,MIP-1alpha-R,RANTES-R |
| 6 | F (S) | scFv16 | polymer | 256 | 27340.5 | 1 | Homo sapiens | ||
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
L: 26 - 92 (UniProt: Q16663)
R: 1 - 355 (UniProt: P32246)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 93 | - | expression tag |
| Ser 94 | - | expression tag |
| Gly 95 | - | expression tag |
| Glu 96 | - | expression tag |
| Asn 97 | - | expression tag |
| Leu 98 | - | expression tag |
| Tyr 99 | - | expression tag |
| Phe 100 | - | expression tag |
| Gln 101 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Leu 356 | - | expression tag |
| Glu 357 | - | expression tag |
| Val 358 | - | expression tag |
| Leu 359 | - | expression tag |
| Phe 360 | - | expression tag |
| Gln 361 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 163913.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 164299.7 |
