7VH0

MT2-remalteon-Gi complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Melatonin receptor type 1B	polymer	362	40308.3	1	UniProt (P49286) Pfam (PF00001)	Homo sapiens (human)	Mel-1B-R,Mel1b receptor
2	B (B)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40340.9	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
3	C (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	353	39021.6	1	UniProt (P54311) Pfam (PF25391)	Rattus norvegicus (Norway rat)	Transducin beta chain 1
4	D, E (D, E)	scFv16	polymer	323	34767.0	2		Homo sapiens (Bovine)
5	F (A)	N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide	non-polymer		259.3	1	Chemie (JEV)

Sequence modifications

A: 1 - 362 (UniProt: P49286)

PDB	External Database	Details
Phe 108	Leu 108	conflict
Trp 129	Phe 129	conflict
Leu 140	Cys 140	conflict

B: 2 - 354 (UniProt: P63096)

PDB	External Database	Details
Gly 1	-	expression tag

C: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Glu 6	Gln 6	conflict
Gln 130	Glu 130	conflict
Asp 237	Asn 237	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	189204.9
Non-Polymers*	Number of molecules	1
	Total formula weight	259.3
All*	Total formula weight	189464.2

*Water molecules are not included.