7VGX
Neuropeptide Y Y1 Receptor (NPY1R) in Complex with G Protein and its endogeneous Peptide-Agonist Neuropeptide Y (NPY)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Neuropeptide Y receptor type 1 | polymer | 402 | 46490.0 | 1 | UniProt (P25929) Pfam (PF00001) | Homo sapiens (Human) | NPY1-R |
| 2 | B (L) | Neuropeptide Y | polymer | 36 | 4277.7 | 1 | UniProt (P01303) Pfam (PF00159) | Homo sapiens | Neuropeptide tyrosine,NPY |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 355 | 40428.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 6 | F (S) | single-chain antibody Fv fragment (scFv16) | polymer | 259 | 27784.9 | 1 | Mus musculus (Mouse) |
Sequence modifications
R: 1 - 384 (UniProt: P25929)
A: 2 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
G: 1 - 71 (UniProt: P59768)
| PDB | External Database | Details |
|---|---|---|
| Asp -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Ala 385 | - | expression tag |
| Ser 386 | - | expression tag |
| Leu 387 | - | expression tag |
| Glu 388 | - | expression tag |
| Val 389 | - | expression tag |
| Leu 390 | - | expression tag |
| Phe 391 | - | expression tag |
| Gln 392 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 164553.8 | |
| All* | Total formula weight | 164553.8 |
