7VFX
The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | fMet-Leu-Phe receptor | polymer | 378 | 41883.9 | 1 | UniProt (P21462) Pfam (PF00001) In PDB | Homo sapiens (Human) | fMLP receptor,N-formyl peptide receptor,FPR,N-formylpeptide chemoattractant receptor |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39286.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
5 | S | scFv16 | polymer | 269 | 28813.0 | 1 | Mus musculus | ||
6 | C | Peptide agonist fMIFL | polymer | 4 | 550.7 | 1 | Staphylococcus aureus | ||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
8 | R | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) |
Sequence modifications
R: 1 - 350 (UniProt: P21462)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp -17 | - | expression tag |
Tyr -16 | - | expression tag |
Lys -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Lys -10 | - | expression tag |
Leu -9 | - | expression tag |
Glu -8 | - | expression tag |
Val -7 | - | expression tag |
Leu -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
His 351 | - | expression tag |
His 352 | - | expression tag |
His 353 | - | expression tag |
His 354 | - | expression tag |
His 355 | - | expression tag |
His 356 | - | expression tag |
His 357 | - | expression tag |
His 358 | - | expression tag |
His 359 | - | expression tag |
His 360 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 158810.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1416.4 | |
All* | Total formula weight | 160227.1 |