7VDP
The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cyclin-dependent-like kinase 5 | polymer | 292 | 33306.3 | 2 | UniProt (Q00535) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 5 |
| 2 | C, D (C, D) | Cyclin-dependent kinase 5 activator 1, p25 | polymer | 209 | 23331.9 | 2 | UniProt (Q15078) Pfam (PF03261) | Homo sapiens (Human) | |
| 3 | E, V (A, B) | [1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol | non-polymer | 434.5 | 2 | Chemie (65L) | |||
| 4 | F, G, H, I, J... (A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | M, N (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | O, P, Q, R, S... (A, C) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 7 | U (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 292 (UniProt: Q00535)
C, D: 100 - 307 (UniProt: Q15078)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 99 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113276.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2042.1 | |
| All* | Total formula weight | 115318.6 |
