7VDP

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cyclin-dependent-like kinase 5	polymer	292	33306.3	2	UniProt (Q00535) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 5
2	C, D	Cyclin-dependent kinase 5 activator 1, p25	polymer	209	23331.9	2	UniProt (Q15078) Pfam (PF03261) In PDB	Homo sapiens (Human)
3	A, B	[1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol	non-polymer		434.5	2	Chemie (65L)
4	A, C	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
5	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6	A, C	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
7	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8		water	water		18.0	372	Chemie (HOH)

Sequence modifications

A, B: 2 - 292 (UniProt: Q00535)

PDB	External Database	Details
Ser 1	-	expression tag

C, D: 100 - 307 (UniProt: Q15078)

PDB	External Database	Details
Met 99	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113276.4
Non-Polymers*	Number of molecules	22
	Total formula weight	2042.1
All*	Total formula weight	115318.6

*Water molecules are not included.