7VBV
Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | polymer | 394 | 44647.7 | 2 | UniProt (Q15119) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 2,PDH kinase 2,PDKII |
| 2 | C, D, E, J, K (A, B) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 3 | F, G, L, M (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 4 | H, N (A, B) | methyl 8-cyclopropyl-2-methyl-9H-pyrido[2,3-b]indole-3-carboxylate | non-polymer | 280.3 | 2 | Chemie (67V) | |||
| 5 | I (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | O, P (A, B) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 407 (UniProt: Q15119)
| PDB | External Database | Details |
|---|---|---|
| Gly 14 | - | expression tag |
| Ser 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89295.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1203.8 | |
| All* | Total formula weight | 90499.3 |
