7VAG

Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium/bile acid cotransporter	polymer	343	38141.8	1	UniProt (Q14973) Pfam (PF01758)	Homo sapiens (Human)	Cell growth-inhibiting gene 29 protein,Na(+)/bile acid cotransporter,Na(+)/taurocholate transport protein,Sodium/taurocholate cotransporting polypeptide,Solute carrier family 10 member 1
2	B (H)	Fab heavy chain from antibody IgG clone number YN69202	polymer	249	26574.7	1		Mus musculus
3	C (L)	Fab light chain from antibody IgG clone number YN69202	polymer	219	24324.0	1		Mus musculus

Sequence modifications

A: 1 - 319 (UniProt: Q14973)

PDB	External Database	Details
Ala 261	Gln 261	engineered mutation
Ile 320	-	expression tag
Glu 321	-	expression tag
Asn 322	-	expression tag
Leu 323	-	expression tag
Tyr 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Asp 328	-	expression tag
Tyr 329	-	expression tag
Lys 330	-	expression tag
Asp 331	-	expression tag
Asp 332	-	expression tag
Asp 333	-	expression tag
Asp 334	-	expression tag
Lys 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	89040.5
All*	Total formula weight	89040.5

*Water molecules are not included.