7V8A
Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein | polymer | 1281 | 142047.2 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | S glycoprotein,E2,Peplomer protein |
2 | F, G, H | Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain | polymer | 861 | 98273.5 | 3 | UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF01353) UniProt (by SIFTS) (A0A059PIQ0) In PDB | Homo sapiens (Human) | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15 |
3 | a, b, c, d, e... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 38 | In PDB GlyTouCan (G42666HT) | |||
4 | C, F, G, H, A... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1206 (UniProt: P0DTC2)
F, G, H: 1 - 615 (UniProt: Q9BYF1)
F, G, H: 616 - 861 (PDB: 7V8A)
PDB | External Database | Details |
---|---|---|
Arg 19 | Thr 19 | variant |
Asp 142 | Gly 142 | variant |
Gly 156 | Glu 156 | variant |
- | Phe 157 | deletion |
- | Arg 158 | deletion |
Arg 450 | Leu 452 | variant |
Lys 476 | Thr 478 | variant |
Gly 612 | Asp 614 | variant |
Arg 679 | Pro 681 | engineered mutation |
Gly 680 | Arg 682 | engineered mutation |
Ser 681 | Arg 683 | engineered mutation |
Ser 683 | Arg 685 | engineered mutation |
Asn 948 | Asp 950 | variant |
Pro 984 | Lys 986 | engineered mutation |
Pro 985 | Val 987 | engineered mutation |
Glu 1207 | - | expression tag |
Phe 1208 | - | expression tag |
Gly 1209 | - | expression tag |
Ser 1210 | - | expression tag |
Gly 1211 | - | expression tag |
Gly 1212 | - | expression tag |
Tyr 1213 | - | expression tag |
Ile 1214 | - | expression tag |
Pro 1215 | - | expression tag |
Glu 1216 | - | expression tag |
Ala 1217 | - | expression tag |
Pro 1218 | - | expression tag |
Arg 1219 | - | expression tag |
Asp 1220 | - | expression tag |
Gly 1221 | - | expression tag |
Gln 1222 | - | expression tag |
Ala 1223 | - | expression tag |
Tyr 1224 | - | expression tag |
Val 1225 | - | expression tag |
Arg 1226 | - | expression tag |
Lys 1227 | - | expression tag |
Asp 1228 | - | expression tag |
Gly 1229 | - | expression tag |
Glu 1230 | - | expression tag |
Trp 1231 | - | expression tag |
Val 1232 | - | expression tag |
Leu 1233 | - | expression tag |
Leu 1234 | - | expression tag |
Ser 1235 | - | expression tag |
Thr 1236 | - | expression tag |
Phe 1237 | - | expression tag |
Leu 1238 | - | expression tag |
Lys 1239 | - | expression tag |
Gly 1240 | - | expression tag |
Gln 1241 | - | expression tag |
Asp 1242 | - | expression tag |
Asn 1243 | - | expression tag |
Ser 1244 | - | expression tag |
Ala 1245 | - | expression tag |
Asp 1246 | - | expression tag |
Ile 1247 | - | expression tag |
Gln 1248 | - | expression tag |
His 1249 | - | expression tag |
Ser 1250 | - | expression tag |
Gly 1251 | - | expression tag |
Arg 1252 | - | expression tag |
Pro 1253 | - | expression tag |
Leu 1254 | - | expression tag |
Glu 1255 | - | expression tag |
Ser 1256 | - | expression tag |
Arg 1257 | - | expression tag |
Gly 1258 | - | expression tag |
Pro 1259 | - | expression tag |
Phe 1260 | - | expression tag |
Glu 1261 | - | expression tag |
Gln 1262 | - | expression tag |
Lys 1263 | - | expression tag |
Leu 1264 | - | expression tag |
Ile 1265 | - | expression tag |
Ser 1266 | - | expression tag |
Glu 1267 | - | expression tag |
Glu 1268 | - | expression tag |
Asp 1269 | - | expression tag |
Leu 1270 | - | expression tag |
Asn 1271 | - | expression tag |
Met 1272 | - | expression tag |
His 1273 | - | expression tag |
Thr 1274 | - | expression tag |
Gly 1275 | - | expression tag |
His 1276 | - | expression tag |
His 1277 | - | expression tag |
His 1278 | - | expression tag |
His 1279 | - | expression tag |
His 1280 | - | expression tag |
His 1281 | - | expression tag |
F, G, H: 616 - 861 (PDB: 7V8A)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 720962.0 | |
Branched | Number of molecules | 38 |
Total formula weight | 16127.2 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 3539.3 | |
All* | Total formula weight | 740628.6 |