7V85
Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein | polymer | 1283 | 142266.4 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | S glycoprotein,E2,Peplomer protein |
2 | F, H | Angiotensin-converting enzyme 2,Green fluorescent protein | polymer | 861 | 98273.5 | 2 | UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF01353) UniProt (by SIFTS) (A0A059PIQ0) In PDB | Homo sapiens | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15 |
3 | a, b, c, d, e... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 31 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1208 (UniProt: P0DTC2)
F, H: 1 - 615 (UniProt: Q9BYF1)
F, H: 616 - 861 (PDB: 7V85)
PDB | External Database | Details |
---|---|---|
Asp 142 | Gly 142 | variant |
Lys 154 | Glu 154 | engineered mutation |
Arg 452 | Leu 452 | variant |
Gln 484 | Glu 484 | engineered mutation |
Gly 614 | Asp 614 | variant |
Gly 682 | Arg 682 | engineered mutation |
Ser 683 | Arg 683 | engineered mutation |
Ser 685 | Arg 685 | engineered mutation |
Pro 986 | Lys 986 | engineered mutation |
Pro 987 | Val 987 | engineered mutation |
His 1071 | Gln 1071 | engineered mutation |
Asp 1101 | His 1101 | engineered mutation |
Glu 1209 | - | expression tag |
Phe 1210 | - | expression tag |
Gly 1211 | - | expression tag |
Ser 1212 | - | expression tag |
Gly 1213 | - | expression tag |
Gly 1214 | - | expression tag |
Tyr 1215 | - | expression tag |
Ile 1216 | - | expression tag |
Pro 1217 | - | expression tag |
Glu 1218 | - | expression tag |
Ala 1219 | - | expression tag |
Pro 1220 | - | expression tag |
Arg 1221 | - | expression tag |
Asp 1222 | - | expression tag |
Gly 1223 | - | expression tag |
Gln 1224 | - | expression tag |
Ala 1225 | - | expression tag |
Tyr 1226 | - | expression tag |
Val 1227 | - | expression tag |
Arg 1228 | - | expression tag |
Lys 1229 | - | expression tag |
Asp 1230 | - | expression tag |
Gly 1231 | - | expression tag |
Glu 1232 | - | expression tag |
Trp 1233 | - | expression tag |
Val 1234 | - | expression tag |
Leu 1235 | - | expression tag |
Leu 1236 | - | expression tag |
Ser 1237 | - | expression tag |
Thr 1238 | - | expression tag |
Phe 1239 | - | expression tag |
Leu 1240 | - | expression tag |
Lys 1241 | - | expression tag |
Gly 1242 | - | expression tag |
Gln 1243 | - | expression tag |
Asp 1244 | - | expression tag |
Asn 1245 | - | expression tag |
Ser 1246 | - | expression tag |
Ala 1247 | - | expression tag |
Asp 1248 | - | expression tag |
Ile 1249 | - | expression tag |
Gln 1250 | - | expression tag |
His 1251 | - | expression tag |
Ser 1252 | - | expression tag |
Gly 1253 | - | expression tag |
Arg 1254 | - | expression tag |
Pro 1255 | - | expression tag |
Leu 1256 | - | expression tag |
Glu 1257 | - | expression tag |
Ser 1258 | - | expression tag |
Arg 1259 | - | expression tag |
Gly 1260 | - | expression tag |
Pro 1261 | - | expression tag |
Phe 1262 | - | expression tag |
Glu 1263 | - | expression tag |
Gln 1264 | - | expression tag |
Lys 1265 | - | expression tag |
Leu 1266 | - | expression tag |
Ile 1267 | - | expression tag |
Ser 1268 | - | expression tag |
Glu 1269 | - | expression tag |
Glu 1270 | - | expression tag |
Asp 1271 | - | expression tag |
Leu 1272 | - | expression tag |
Asn 1273 | - | expression tag |
Met 1274 | - | expression tag |
His 1275 | - | expression tag |
Thr 1276 | - | expression tag |
Gly 1277 | - | expression tag |
His 1278 | - | expression tag |
His 1279 | - | expression tag |
His 1280 | - | expression tag |
His 1281 | - | expression tag |
His 1282 | - | expression tag |
His 1283 | - | expression tag |
F, H: 616 - 861 (PDB: 7V85)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 623346.2 | |
Branched | Number of molecules | 31 |
Total formula weight | 13156.4 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2875.7 | |
All* | Total formula weight | 639378.4 |