7V3Z

Structure of cannabinoid receptor type 1(CB1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	fusion protein of Cannabinoid receptor 1 and Flavodoxin	polymer	438	48602.6	1	UniProt (P21554) UniProt (P00323) Pfam (PF00001) Pfam (PF00258)	Homo sapiens (Human)	CB-R,CB1,CANN6
2	B (A)	2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol	non-polymer		376.6	1	Chemie (9GF)
3	C (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
4	D (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)

Sequence modifications

A: 102 - 306 (UniProt: P21554)

PDB	External Database	Details
Gly 99	-	expression tag
Glu 100	-	expression tag
Asn 101	-	expression tag
Leu 154	His 154	engineered mutation
Ala 210	Thr 210	engineered mutation
Lys 273	Glu 273	engineered mutation
Val 283	Thr 283	engineered mutation

A: 308 - 453 (UniProt: P00323)

PDB	External Database	Details
Trp 403	Tyr 98	engineered mutation
Pro	-	linker
Asp	-	linker
Gln	-	linker
Ala	-	linker

A: 458 - 536 (UniProt: P21554)

PDB	External Database	Details
Ala 307	-	linker
Glu 462	Arg 340	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48602.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1219.6
All*	Total formula weight	49822.2

*Water molecules are not included.