7V18
Factor XIa in Complex with Compound 3f
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Coagulation factor XIa light chain | polymer | 238 | 26856.5 | 1 | UniProt (P03951) Pfam (PF00089) In PDB | Homo sapiens (human) | FXI,Plasma thromboplastin antecedent,PTA |
| 2 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 3 | A | 2-[(1~{R})-3-[bis(fluoranyl)methoxy]-1-[4-(3-methyl-1,2,3-triazol-4-yl)pyrazol-1-yl]propyl]-5-[3-chloranyl-6-(4-chloranyl-1,2,3-triazol-1-yl)-2-fluoranyl-phenyl]-1-oxidanyl-pyridine | non-polymer | 580.3 | 1 | Chemie (OTX) | |||
| 4 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 388 - 625 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ser 500 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26856.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 772.5 | |
| All* | Total formula weight | 27629.0 |
