7UYZ
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Cyclic GMP-AMP synthase | polymer | 364 | 42640.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, D, E, F (E, F, I, J) | Palindromic DNA18 | polymer | 18 | 5514.6 | 4 | DNA molecule | ||
| 3 | G, H, L, M (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | I, N (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | J, O (A, C) | GUANOSINE-5'-MONOPHOSPHATE | non-polymer | 363.2 | 2 | Chemie (5GP) | |||
| 6 | K, P (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 7 | Q, R, S, T, U (A, C, E, F, I) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, C: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Gly 144 | - | expression tag |
| Thr 145 | - | expression tag |
| Gly 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107338.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2000.8 | |
| All* | Total formula weight | 109339.8 |
