7UYV
Crystal structure of JAK3 kinase domain in complex with compound 25
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase JAK3 | polymer | 291 | 33275.9 | 4 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | E, F, G, H (A, B, C, D) | 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide | non-polymer | 423.8 | 4 | Chemie (OV5) | |||
| 3 | I (D) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 438 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 810 - 1100 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 1040 | Cys 1040 | conflict |
| Ser 1048 | Cys 1048 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 133103.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1730.8 | |
| All* | Total formula weight | 134834.2 |
