7UYQ
Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Cyclic GMP-AMP synthase | polymer | 364 | 42638.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, D, E, F (E, F, I, J) | Palindromic DNA18 | polymer | 18 | 5514.6 | 4 | DNA molecule | ||
| 3 | G, H, K, L (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | I, M (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | J, N (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | O, P, Q, R, S (A, C, E, F, I) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, C: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Gly 144 | - | expression tag |
| Thr 145 | - | expression tag |
| Gly 146 | - | expression tag |
| Gln 211 | Glu 211 | engineered mutation |
| Asn 213 | Asp 213 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107335.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2272.1 | |
| All* | Total formula weight | 109607.1 |
