7UWL

Structure of the IL-25-IL-17RB-IL-17RA ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-25	polymer	188	21490.2	2	UniProt (Q9H293) Pfam (PF06083)	Homo sapiens (human)	IL-25,Interleukin-17E,IL-17E
2	C, D (C, D)	Interleukin-17 receptor B	polymer	305	33649.1	2	UniProt (Q9NRM6) Pfam (PF16556) Pfam (PF16578)	Homo sapiens (human)	IL-17 receptor B,IL-17RB,Cytokine receptor-like 4,IL-17 receptor homolog 1,IL-17Rh1,IL17Rh1,Interleukin-17B receptor,IL-17B receptor
3	E, F (E, F)	Interleukin-17 receptor A	polymer	319	36888.6	2	UniProt (Q96F46) Pfam (PF16556) Pfam (PF16578)	Homo sapiens (human)	IL-17 receptor A,IL-17RA,CDw217
4	G, H, I, J (G, H, I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	K, L, M, N, O... (A, B, C, D, E...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	14	Chemie (NAG)

Sequence modifications

A, B: 30 - 177 (UniProt: Q9H293)

PDB	External Database	Details
Asp 26	-	expression tag
Ala 27	-	expression tag
Ser 28	-	expression tag
Ala 29	-	expression tag
Ala 178	-	expression tag
Pro 179	-	expression tag
Ala 180	-	expression tag
Ala 181	-	expression tag
Leu 182	-	expression tag
Glu 183	-	expression tag
Val 184	-	expression tag
Leu 185	-	expression tag
Phe 186	-	expression tag
Gln 187	-	expression tag
Gly 188	-	expression tag
Pro 189	-	expression tag
Gly 190	-	expression tag
Ala 191	-	expression tag
Ala 192	-	expression tag
Gly 193	-	expression tag
Leu 194	-	expression tag
Asn 195	-	expression tag
Asp 196	-	expression tag
Ile 197	-	expression tag
Phe 198	-	expression tag
Glu 199	-	expression tag
Ala 200	-	expression tag
Gln 201	-	expression tag
Lys 202	-	expression tag
Ile 203	-	expression tag
Glu 204	-	expression tag
Trp 205	-	expression tag
His 206	-	expression tag
Glu 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag

C, D: 18 - 288 (UniProt: Q9NRM6)

PDB	External Database	Details
Ala 289	-	expression tag
Ala 290	-	expression tag
Ala 291	-	expression tag
Leu 292	-	expression tag
Glu 293	-	expression tag
Val 294	-	expression tag
Leu 295	-	expression tag
Phe 296	-	expression tag
Gln 297	-	expression tag
Gly 298	-	expression tag
Pro 299	-	expression tag
Gly 300	-	expression tag
Ala 301	-	expression tag
Ala 302	-	expression tag
Glu 303	-	expression tag
Asp 304	-	expression tag
Gln 305	-	expression tag
Val 306	-	expression tag
Asp 307	-	expression tag
Pro 308	-	expression tag
Arg 309	-	expression tag
Leu 310	-	expression tag
Ile 311	-	expression tag
Asp 312	-	expression tag
Gly 313	-	expression tag
Lys 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag

E, F: 33 - 317 (UniProt: Q96F46)

PDB	External Database	Details
Ser 318	-	expression tag
Ala 319	-	expression tag
Ala 320	-	expression tag
Leu 321	-	expression tag
Glu 322	-	expression tag
Val 323	-	expression tag
Leu 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Pro 328	-	expression tag
Gly 329	-	expression tag
Ala 330	-	expression tag
Ala 331	-	expression tag
Glu 332	-	expression tag
Asp 333	-	expression tag
Gln 334	-	expression tag
Val 335	-	expression tag
Asp 336	-	expression tag
Pro 337	-	expression tag
Arg 338	-	expression tag
Leu 339	-	expression tag
Ile 340	-	expression tag
Asp 341	-	expression tag
Gly 342	-	expression tag
Lys 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	184055.8
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	14
	Total formula weight	3096.9
All*	Total formula weight	188850.3

*Water molecules are not included.