7UU0

Crystal structure of the BRD2-BD2 in complex with a ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 3 of Bromodomain-containing protein 2	polymer	135	15847.1	1	UniProt (P25440) Pfam (PF00439)	Homo sapiens (human)	O27.1.1,Really interesting new gene 3 protein
2	B (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
3	C (A)	methyl (7S)-7-(thiophen-2-yl)-1,4-thiazepane-4-carboxylate	non-polymer		257.4	1	Chemie (QJ1)
4	D (A)	water	water		18.0	242	Chemie (HOH)

Sequence modifications

A: 344 - 455 (UniProt: P25440)

PDB	External Database	Details
Met 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
Ser 328	-	expression tag
Ser 329	-	expression tag
Gly 330	-	expression tag
Val 331	-	expression tag
Asp 332	-	expression tag
Leu 333	-	expression tag
Gly 334	-	expression tag
Thr 335	-	expression tag
Glu 336	-	expression tag
Asn 337	-	expression tag
Leu 338	-	expression tag
Tyr 339	-	expression tag
Phe 340	-	expression tag
Gln 341	-	expression tag
Ser 342	-	expression tag
Met 343	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15847.1
Non-Polymers*	Number of molecules	2
	Total formula weight	319.4
All*	Total formula weight	16166.5

*Water molecules are not included.