7USL

Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-M	polymer	1162	128455.3	1	UniProt (P11215) Pfam (PF00092) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF21520)	Homo sapiens (human)	CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor
2	B (B)	Integrin beta	polymer	730	80784.9	1	UniProt (A0A494C0X7) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF23105) UniProt (by SIFTS) (P05107)	Homo sapiens (human)
3	C (C)	Bifunctional hemolysin-adenylate cyclase	polymer	960	100286.7	1	UniProt (A5JW88) Pfam (PF02382) Pfam (PF00353) Pfam (PF06594) UniProt (by SIFTS) (P0DKX7)	Bordetella pertussis
4	D (H)	M1F5 fab heavy chain	polymer	228	24665.7	1		Homo sapiens (Human)
5	E (L)	M1F5 fab light chain	polymer	213	23360.9	1		Homo sapiens (Human)
6	F (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
8	AA, BA, CA, DA, EA... (C, A, B)	CALCIUM ION	non-polymer		40.1	33	Chemie (CA)
9	K, L, M, N, O... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)

Sequence modifications

A: 1 - 1088 (UniProt: P11215)

PDB	External Database	Details
Gly 1089	-	expression tag
Cys 1090	-	expression tag
Gly 1091	-	expression tag
Gly 1092	-	expression tag
Leu 1093	-	expression tag
Glu 1094	-	expression tag
Val 1095	-	expression tag
Leu 1096	-	expression tag
Phe 1097	-	expression tag
Gln 1098	-	expression tag
Gly 1099	-	expression tag
Pro 1100	-	expression tag
Gly 1101	-	expression tag
Glu 1102	-	expression tag
Asn 1103	-	expression tag
Ala 1104	-	expression tag
Gln 1105	-	expression tag
Cys 1106	-	expression tag
Glu 1107	-	expression tag
Lys 1108	-	expression tag
Glu 1109	-	expression tag
Leu 1110	-	expression tag
Gln 1111	-	expression tag
Ala 1112	-	expression tag
Leu 1113	-	expression tag
Glu 1114	-	expression tag
Lys 1115	-	expression tag
Glu 1116	-	expression tag
Asn 1117	-	expression tag
Ala 1118	-	expression tag
Gln 1119	-	expression tag
Leu 1120	-	expression tag
Glu 1121	-	expression tag
Trp 1122	-	expression tag
Glu 1123	-	expression tag
Leu 1124	-	expression tag
Gln 1125	-	expression tag
Ala 1126	-	expression tag
Leu 1127	-	expression tag
Glu 1128	-	expression tag
Lys 1129	-	expression tag
Glu 1130	-	expression tag
Leu 1131	-	expression tag
Ala 1132	-	expression tag
Gln 1133	-	expression tag
Trp 1134	-	expression tag
Ser 1135	-	expression tag
His 1136	-	expression tag
Pro 1137	-	expression tag
Gln 1138	-	expression tag
Phe 1139	-	expression tag
Glu 1140	-	expression tag
Lys 1141	-	expression tag
Gly 1142	-	expression tag
Gly 1143	-	expression tag
Gly 1144	-	expression tag
Ser 1145	-	expression tag
Gly 1146	-	expression tag
Gly 1147	-	expression tag
Gly 1148	-	expression tag
Gly 1149	-	expression tag
Ser 1150	-	expression tag
Gly 1151	-	expression tag
Gly 1152	-	expression tag
Ser 1153	-	expression tag
Ala 1154	-	expression tag
Trp 1155	-	expression tag
Ser 1156	-	expression tag
His 1157	-	expression tag
Pro 1158	-	expression tag
Gln 1159	-	expression tag
Phe 1160	-	expression tag
Glu 1161	-	expression tag
Lys 1162	-	expression tag

B: 1 - 677 (UniProt: A0A494C0X7)

PDB	External Database	Details
Asp 678	-	expression tag
Gly 679	-	expression tag
Cys 680	-	expression tag
Gly 681	-	expression tag
Leu 682	-	expression tag
Glu 683	-	expression tag
Val 684	-	expression tag
Leu 685	-	expression tag
Phe 686	-	expression tag
Gln 687	-	expression tag
Gly 688	-	expression tag
Pro 689	-	expression tag
Gly 690	-	expression tag
Lys 691	-	expression tag
Asn 692	-	expression tag
Ala 693	-	expression tag
Gln 694	-	expression tag
Cys 695	-	expression tag
Lys 696	-	expression tag
Lys 697	-	expression tag
Lys 698	-	expression tag
Leu 699	-	expression tag
Gln 700	-	expression tag
Ala 701	-	expression tag
Leu 702	-	expression tag
Lys 703	-	expression tag
Lys 704	-	expression tag
Lys 705	-	expression tag
Asn 706	-	expression tag
Ala 707	-	expression tag
Gln 708	-	expression tag
Leu 709	-	expression tag
Lys 710	-	expression tag
Trp 711	-	expression tag
Lys 712	-	expression tag
Leu 713	-	expression tag
Gln 714	-	expression tag
Ala 715	-	expression tag
Leu 716	-	expression tag
Lys 717	-	expression tag
Lys 718	-	expression tag
Lys 719	-	expression tag
Leu 720	-	expression tag
Ala 721	-	expression tag
Gln 722	-	expression tag
Gly 723	-	expression tag
Gly 724	-	expression tag
His 725	-	expression tag
His 726	-	expression tag
His 727	-	expression tag
His 728	-	expression tag
His 729	-	expression tag
His 730	-	expression tag

C: 751 - 1706 (UniProt: A5JW88)

PDB	External Database	Details
Gly 747	-	expression tag
Pro 748	-	expression tag
Gly 749	-	expression tag
Ser 750	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	357553.5
Branched	Number of molecules	2
	Total formula weight	994.9
Non-Polymers*	Number of molecules	44
	Total formula weight	3755.9
All*	Total formula weight	362304.3

*Water molecules are not included.