7URC
Human PORCN in complex with LGK974
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine | polymer | 464 | 52824.7 | 1 | UniProt (Q9H237) Pfam (PF03062) In PDB | Homo sapiens (human) | Protein MG61 |
2 | L | 2C11 light chain | polymer | 234 | 25673.7 | 1 | Mus musculus (Mouse) | ||
3 | H | 2C11 heavy chain | polymer | 250 | 26933.1 | 1 | Mus musculus (Mouse) | ||
4 | A | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide | non-polymer | 396.4 | 1 | Chemie (O50) | |||
5 | A | CHOLESTEROL | non-polymer | 386.7 | 9 | Chemie (CLR) | |||
6 | A | Digitonin | non-polymer | 1229.3 | 1 | Chemie (AJP) | |||
7 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 2 - 456 (UniProt: Q9H237)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 105431.5 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 5171.1 | |
All* | Total formula weight | 110602.5 |