7URC
Human PORCN in complex with LGK974
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine | polymer | 464 | 52824.7 | 1 | UniProt (Q9H237) Pfam (PF03062) | Homo sapiens (human) | Protein MG61 |
| 2 | B (L) | 2C11 light chain | polymer | 234 | 25673.7 | 1 | Mus musculus (Mouse) | ||
| 3 | C (H) | 2C11 heavy chain | polymer | 250 | 26933.1 | 1 | Mus musculus (Mouse) | ||
| 4 | D (A) | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide | non-polymer | 396.4 | 1 | Chemie (O50) | |||
| 5 | E, F, G, H, I... (A) | CHOLESTEROL | non-polymer | 386.7 | 9 | Chemie (CLR) | |||
| 6 | N (A) | Digitonin | non-polymer | 1229.3 | 1 | Chemie (AJP) | |||
| 7 | O (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 2 - 456 (UniProt: Q9H237)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 105431.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5171.1 | |
| All* | Total formula weight | 110602.5 |
