7UR4
Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Fusion glycoprotein F0 | polymer | 551 | 60489.9 | 3 | UniProt (H6X1Z1) Pfam (PF00523) UniProt (by SIFTS) (Q6WB98) In PDB | Human metapneumovirus | |
2 | F, H, I | MPV467 Fab Heavy chain | polymer | 223 | 24023.8 | 3 | Homo sapiens (Human) | ||
3 | G, J, L | MPV467 Fab Light chain | polymer | 211 | 22621.9 | 3 | Homo sapiens (Human) | ||
4 | D, E, K | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
5 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 490 (UniProt: H6X1Z1)
PDB | External Database | Details |
---|---|---|
Cys 84 | Val 84 | engineered mutation |
Arg 100 | Gln 100 | engineered mutation |
Arg 101 | Ser 101 | engineered mutation |
Cys 110 | Leu 110 | engineered mutation |
Cys 127 | Thr 127 | engineered mutation |
Cys 140 | Ala 140 | engineered mutation |
Cys 147 | Ala 147 | engineered mutation |
Cys 153 | Asn 153 | engineered mutation |
Pro 185 | Ala 185 | engineered mutation |
Lys 219 | Leu 219 | engineered mutation |
Ile 231 | Val 231 | engineered mutation |
Cys 249 | Ala 249 | engineered mutation |
Cys 322 | Asn 322 | engineered mutation |
Cys 365 | Thr 365 | engineered mutation |
Gln 453 | Glu 453 | engineered mutation |
Cys 463 | Val 463 | engineered mutation |
Gly 491 | - | expression tag |
Gly 492 | - | expression tag |
Gly 493 | - | expression tag |
Ser 494 | - | expression tag |
Gly 495 | - | expression tag |
Tyr 496 | - | expression tag |
Ile 497 | - | expression tag |
Pro 498 | - | expression tag |
Glu 499 | - | expression tag |
Ala 500 | - | expression tag |
Pro 501 | - | expression tag |
Arg 502 | - | expression tag |
Asp 503 | - | expression tag |
Gly 504 | - | expression tag |
Gln 505 | - | expression tag |
Ala 506 | - | expression tag |
Tyr 507 | - | expression tag |
Val 508 | - | expression tag |
Arg 509 | - | expression tag |
Lys 510 | - | expression tag |
Asp 511 | - | expression tag |
Gly 512 | - | expression tag |
Glu 513 | - | expression tag |
Trp 514 | - | expression tag |
Val 515 | - | expression tag |
Leu 516 | - | expression tag |
Leu 517 | - | expression tag |
Ser 518 | - | expression tag |
Thr 519 | - | expression tag |
Phe 520 | - | expression tag |
Leu 521 | - | expression tag |
Gly 522 | - | expression tag |
Arg 523 | - | expression tag |
Ser 524 | - | expression tag |
Leu 525 | - | expression tag |
Glu 526 | - | expression tag |
Val 527 | - | expression tag |
Leu 528 | - | expression tag |
Phe 529 | - | expression tag |
Gln 530 | - | expression tag |
Gly 531 | - | expression tag |
Pro 532 | - | expression tag |
Gly 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
His 537 | - | expression tag |
His 538 | - | expression tag |
His 539 | - | expression tag |
His 540 | - | expression tag |
His 541 | - | expression tag |
Ser 542 | - | expression tag |
Ala 543 | - | expression tag |
Trp 544 | - | expression tag |
Ser 545 | - | expression tag |
His 546 | - | expression tag |
Pro 547 | - | expression tag |
Gln 548 | - | expression tag |
Phe 549 | - | expression tag |
Glu 550 | - | expression tag |
Lys 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 321406.9 | |
Branched | Number of molecules | 3 |
Total formula weight | 1759.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 324493.8 |