7UQY
Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Exostosin-1 | polymer | 720 | 83404.0 | 1 | UniProt (Q16394) Pfam (PF03016) Pfam (PF09258) In PDB | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 1,Putative tumor suppressor protein EXT1 |
2 | B | Exostosin-2 | polymer | 674 | 77238.0 | 1 | UniProt (Q93063) Pfam (PF03016) Pfam (PF09258) In PDB | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 2,Putative tumor suppressor protein EXT2 |
3 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | A | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 1 | Chemie (UDP) |
Sequence modifications
A: 28 - 746 (UniProt: Q16394)
B: 46 - 718 (UniProt: Q93063)
PDB | External Database | Details |
---|---|---|
Gly 27 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 45 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 160642.1 | |
Branched | Number of molecules | 1 |
Total formula weight | 586.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 404.2 | |
All* | Total formula weight | 161632.8 |