7UPW
Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Spike glycoprotein | polymer | 1310 | 144858.0 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus | S glycoprotein,E2,Peplomer protein |
| 2 | D, F, H | SP1-77 Fab heavy chain | polymer | 451 | 49665.7 | 3 | Homo sapiens (Human) | ||
| 3 | E, G, L | SP1-77 Fab light chain | polymer | 213 | 23294.6 | 3 | Homo sapiens (Human) | ||
| 4 | h, I, l, N, V... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 5 | a, b, d, e, g... | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 24 | In PDB GlyTouCan (G62182OO) | |||
| 6 | c, f, o, Q, r... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 6 | In PDB GlyTouCan (G21290RB) | |||
| 7 | B, C, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1273 (UniProt: P0DTC2)
D, F, H: 1 - 90 (PDB: 7UPW)
D, F, H: 91 - 102 (PDB: 7UPW)
D, F, H: 103 - 440 (PDB: 7UPW)
E, G, L: 1 - 97 (PDB: 7UPW)
E, G, L: 98 - 108 (PDB: 7UPW)
E, G, L: 109 - 214 (PDB: 7UPW)
| PDB | External Database | Details |
|---|---|---|
| Gly 614 | Asp 614 | engineered mutation |
| Leu 1274 | - | expression tag |
| Glu 1275 | - | expression tag |
| Ser 1276 | - | expression tag |
| Gly 1277 | - | expression tag |
| Gly 1278 | - | expression tag |
| Gly 1279 | - | expression tag |
| Ser 1280 | - | expression tag |
| Ala 1281 | - | expression tag |
| Trp 1282 | - | expression tag |
| Ser 1283 | - | expression tag |
| His 1284 | - | expression tag |
| Pro 1285 | - | expression tag |
| Gln 1286 | - | expression tag |
| Phe 1287 | - | expression tag |
| Glu 1288 | - | expression tag |
| Lys 1289 | - | expression tag |
| Gly 1290 | - | expression tag |
| Gly 1291 | - | expression tag |
| Gly 1292 | - | expression tag |
| Ser 1293 | - | expression tag |
| Gly 1294 | - | expression tag |
| Gly 1295 | - | expression tag |
| Gly 1296 | - | expression tag |
| Ser 1297 | - | expression tag |
| Gly 1298 | - | expression tag |
| Gly 1299 | - | expression tag |
| Ser 1300 | - | expression tag |
| Ser 1301 | - | expression tag |
| Ala 1302 | - | expression tag |
| Trp 1303 | - | expression tag |
| Ser 1304 | - | expression tag |
| His 1305 | - | expression tag |
| Pro 1306 | - | expression tag |
| Gln 1307 | - | expression tag |
| Phe 1308 | - | expression tag |
| Glu 1309 | - | expression tag |
| Lys 1310 | - | expression tag |
D, F, H: 91 - 102 (PDB: 7UPW)
D, F, H: 103 - 440 (PDB: 7UPW)
E, G, L: 1 - 97 (PDB: 7UPW)
E, G, L: 98 - 108 (PDB: 7UPW)
E, G, L: 109 - 214 (PDB: 7UPW)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 653455.1 | |
| Branched | Number of molecules | 36 |
| Total formula weight | 20046.7 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4645.4 | |
| All* | Total formula weight | 678147.1 |
