7UO7

SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase	polymer	932	106781.0	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2	Pol, RdRp, Non-structural protein 12, nsp12
2	B, D	Non-structural protein 8	polymer	198	21903.0	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp8
3	C	Non-structural protein 7	polymer	92	10250.0	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp7
4	P	Product RNA (35-MER)	polymer	35	11157.6	1		synthetic construct
5	T	Template RNA (55-MER)	polymer	55	17641.5	1		synthetic construct
6	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
7	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Val -8	-	expression tag
Ala -7	-	expression tag
Cys -6	-	expression tag
Thr -5	-	expression tag
Lys -4	-	expression tag
Glu -3	-	expression tag
Val -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	189636.2
Non-Polymers*	Number of molecules	4
	Total formula weight	662.3
All*	Total formula weight	190298.5

*Water molecules are not included.