7UNB

Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-117 and RUPA-47

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (L)	RUPA-47 Fab kappa chain	polymer	215	23490.2	1		Homo sapiens
2	B (R)	Gametocyte surface protein P45/48	polymer	147	16515.4	1	UniProt (Q8I6T1) Pfam (PF07422)	Plasmodium falciparum (malaria parasite P. falciparum)
3	C (E)	RUPA-117 Fab kappa chain	polymer	214	23523.2	1		Homo sapiens
4	D (H)	RUPA-47 Fab heavy chain	polymer	223	23725.6	1		Homo sapiens
5	E (F)	RUPA-117 Fab heavy chain	polymer	230	24253.3	1		Homo sapiens
6	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	G, H, I, J, K (L, R, E, H, F)	water	water		18.0	594	Chemie (HOH)

Sequence modifications

R: 291 - 428 (UniProt: Q8I6T1)

PDB	External Database	Details
Tyr 308	His 308	engineered mutation
Leu 397	Gly 397	engineered mutation
Val 402	Ile 402	engineered mutation
Gly 429	-	expression tag
Thr 430	-	expression tag
Lys 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	111507.7
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	111728.9

*Water molecules are not included.