7UM7
CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5-hydroxytryptamine receptor 5A | polymer | 326 | 36884.2 | 1 | UniProt (P47898) Pfam (PF00001) In PDB | Homo sapiens (human) | 5-HT-5,5-HT-5A,5-HT5A,Serotonin receptor 5A |
| 2 | B | miniGo protein | polymer | 225 | 25159.8 | 1 | Homo sapiens (Human) | ||
| 3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 5 | E | Single-chain variable fragment scFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus (Mouse) | ||
| 6 | A | (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide | non-polymer | 339.4 | 1 | Chemie (H8D) |
Sequence modifications
A: 32 - 357 (UniProt: P47898)
| PDB | External Database | Details |
|---|---|---|
| Pro 146 | His 146 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 133870.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 339.4 | |
| All* | Total formula weight | 134210.0 |
