7UL7

Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A, B	Glycoprotein G1	polymer	258	28987.4	3	UniProt (Q9IMJ0) Pfam (PF00798) In PDB	Lassa mammarenavirus
2	D, L, F	18.5C-M30 Fab Light Chain	polymer	237	25880.8	3		Homo sapiens
3	E, H, G	18.5C-M30 Fab Heavy Chain	polymer	249	26737.3	3		Homo sapiens
4	c, b, a	Glycoprotein G2	polymer	206	23348.1	3	UniProt (Q9IMJ0) Pfam (PF00798) In PDB	Lassa mammarenavirus
5	I, J, K, M	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
6	B, c, b, a, C...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	22	Chemie (NAG)

Sequence modifications

C, A, B: 1 - 258 (UniProt: Q9IMJ0)

PDB	External Database	Details
Cys 206	Lys 206	conflict
Arg 257	Leu 257	engineered mutation
Arg 258	Leu 258	engineered mutation

c, b, a: 259 - 418 (UniProt: Q9IMJ0)

PDB	External Database	Details
Pro 328	Glu 328	conflict
Cys 359	Gly 359	conflict
Leu 419	-	expression tag
Pro 420	-	expression tag
Glu 421	-	expression tag
Thr 422	-	expression tag
Gly 423	-	expression tag
Leu 424	-	expression tag
Val 425	-	expression tag
Asp 426	-	expression tag
Leu 427	-	expression tag
Glu 428	-	expression tag
Val 429	-	expression tag
Asp 430	-	expression tag
Asp 431	-	expression tag
Asp 432	-	expression tag
Asp 433	-	expression tag
Lys 434	-	expression tag
Ala 435	-	expression tag
Gly 436	-	expression tag
Trp 437	-	expression tag
Ser 438	-	expression tag
His 439	-	expression tag
Pro 440	-	expression tag
Gln 441	-	expression tag
Phe 442	-	expression tag
Glu 443	-	expression tag
Lys 444	-	expression tag
Gly 445	-	expression tag
Gly 446	-	expression tag
Gly 447	-	expression tag
Ser 448	-	expression tag
Gly 449	-	expression tag
Gly 450	-	expression tag
Gly 451	-	expression tag
Ser 452	-	expression tag
Gly 453	-	expression tag
Gly 454	-	expression tag
Gly 455	-	expression tag
Ser 456	-	expression tag
Trp 457	-	expression tag
Ser 458	-	expression tag
His 459	-	expression tag
Pro 460	-	expression tag
Gln 461	-	expression tag
Phe 462	-	expression tag
Glu 463	-	expression tag
Lys 464	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	314861.0
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	22
	Total formula weight	4866.6
All*	Total formula weight	321425.1

*Water molecules are not included.