7UKS
Crystal structure of SOS1 with phthalazine inhibitor bound (compound 15)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Son of sevenless homolog 1 | polymer | 487 | 57103.3 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (human) | SOS-1 |
| 2 | A | 4-methyl-N-{(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}-7-(piperazin-1-yl)phthalazin-1-amine | non-polymer | 429.5 | 1 | Chemie (NL0) | |||
| 3 | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 564 - 1049 (UniProt: Q07889)
| PDB | External Database | Details |
|---|---|---|
| Gly 563 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57103.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 429.5 | |
| All* | Total formula weight | 57532.8 |
