7UJW
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Possesses Selective Estrogen Receptor Degrader Activities
Replaces: 6VVPEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, D, C, A | Estrogen receptor | polymer | 263 | 30147.2 | 4 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | B, D, C, A | (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol | non-polymer | 427.6 | 4 | Chemie (R3V) | |||
3 | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
B, D, C, A: 306 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
His 292 | - | expression tag |
His 293 | - | expression tag |
His 294 | - | expression tag |
His 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
Glu 298 | - | expression tag |
Asn 299 | - | expression tag |
Leu 300 | - | expression tag |
Tyr 301 | - | expression tag |
Phe 302 | - | expression tag |
Gln 303 | - | expression tag |
Ser 304 | - | expression tag |
Met 305 | - | expression tag |
Ser 381 | Cys 381 | conflict |
Ser 417 | Cys 417 | conflict |
Ser 530 | Cys 530 | conflict |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 120588.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1710.3 | |
All* | Total formula weight | 122299.1 |