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7UJQ

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B

Replaces:  6XBP
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BCalcium/calmodulin-dependent protein kinase type II subunit alphapolymer26830548.12UniProt (Q9UQM7)
Pfam (PF00069)
In PDB
Homo sapiens (human)CaMK-II subunit alpha
2C, DGlutamate receptor ionotropic, NMDA 2Bpolymer222754.22UniProt (Q13224)
In PDB
Homo sapiensGluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3
3A, Bmethyl 6-O-(heptylcarbamoyl)-beta-L-altropyranosidenon-polymer335.42Chemie (UZD)
4BGLYCEROLnon-polymer92.11Chemie (GOL)
5waterwater18.0129Chemie (HOH)
Sequence modifications
A, B: 7 - 274 (UniProt: Q9UQM7)
PDBExternal DatabaseDetails
Asn 135Asp 135engineered mutation
Lys 223Gln 223engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight66604.5
Non-Polymers*Number of molecules3
Total formula weight762.9
All*Total formula weight67367.4
*Water molecules are not included.

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PDB entries from 2024-07-24

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