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7UJP

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B

Replaces:  6XBX
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Calcium/calmodulin-dependent protein kinase type II subunit alphapolymer26830548.12UniProt (Q9UQM7)
Pfam (PF00069)
Homo sapiens (human)CaMK-II subunit alpha
2C, D
(C, D)
Glutamate receptor ionotropic, NMDA 2Bpolymer222754.22UniProt (Q13224)Homo sapiensGluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3
3E
(A)
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
4F, H, J
(A, B, C)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
5G
(B)
ADENOSINE-5'-TRIPHOSPHATEnon-polymer507.21Chemie (ATP)
6I
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
7K, L, M
(A, B, C)
waterwater18.045Chemie (HOH)
Sequence modifications
A, B: 7 - 274 (UniProt: Q9UQM7)
PDBExternal DatabaseDetails
Asn 135Asp 135engineered mutation
Lys 223Gln 223engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight66604.5
Non-Polymers*Number of molecules6
Total formula weight1099.4
All*Total formula weight67703.9
*Water molecules are not included.

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PDB entries from 2025-12-24

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