7UJ4
Inhibition of Human Menin by SNDX-5613
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Isoform 2 of Menin | polymer | 488 | 54767.2 | 2 | UniProt (O00255-2) Pfam (PF05053) UniProt (by SIFTS) (O00255) In PDB | Homo sapiens (human) | |
| 2 | A, B | 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide | non-polymer | 630.8 | 2 | Chemie (OQ4) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 582 (UniProt: O00255-2)
| PDB | External Database | Details |
|---|---|---|
| Thr 5 | Ala 5 | engineered mutation |
| - | Val 458 | deletion |
| - | Ser 459 | deletion |
| - | Arg 460 | deletion |
| - | Glu 461 | deletion |
| - | Ala 462 | deletion |
| - | Glu 463 | deletion |
| - | Ala 464 | deletion |
| - | Ala 465 | deletion |
| - | Glu 466 | deletion |
| - | Ala 467 | deletion |
| - | Glu 468 | deletion |
| - | Glu 469 | deletion |
| - | Pro 470 | deletion |
| - | Trp 471 | deletion |
| - | Gly 472 | deletion |
| - | Glu 473 | deletion |
| - | Glu 474 | deletion |
| - | Ala 475 | deletion |
| - | Arg 476 | deletion |
| - | Glu 477 | deletion |
| - | Gly 478 | deletion |
| - | Arg 479 | deletion |
| - | Arg 480 | deletion |
| - | Arg 481 | deletion |
| - | Gly 482 | deletion |
| - | Pro 483 | deletion |
| - | Arg 484 | deletion |
| - | Arg 485 | deletion |
| - | Glu 486 | deletion |
| - | Ser 487 | deletion |
| - | Lys 488 | deletion |
| - | Pro 489 | deletion |
| - | Glu 490 | deletion |
| - | Glu 491 | deletion |
| - | Pro 492 | deletion |
| - | Pro 493 | deletion |
| - | Pro 494 | deletion |
| - | Pro 495 | deletion |
| - | Lys 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Ala 499 | deletion |
| - | Leu 500 | deletion |
| - | Asp 501 | deletion |
| - | Lys 502 | deletion |
| - | Gly 503 | deletion |
| - | Leu 504 | deletion |
| - | Gly 505 | deletion |
| - | Thr 506 | deletion |
| - | Gly 507 | deletion |
| - | Gln 508 | deletion |
| - | Gly 509 | deletion |
| - | Ala 510 | deletion |
| - | Val 511 | deletion |
| - | Ser 512 | deletion |
| - | Gly 513 | deletion |
| - | Pro 514 | deletion |
| - | Pro 515 | deletion |
| - | Arg 516 | deletion |
| - | Lys 517 | deletion |
| - | Pro 518 | deletion |
| - | Pro 519 | deletion |
| - | Gly 520 | deletion |
| - | Thr 521 | deletion |
| - | Val 522 | deletion |
| - | Ala 523 | deletion |
| - | Gly 524 | deletion |
| - | Thr 525 | deletion |
| - | Ala 526 | deletion |
| - | Arg 527 | deletion |
| - | Gly 528 | deletion |
| - | Pro 529 | deletion |
| - | Glu 530 | deletion |
| - | Gly 531 | deletion |
| - | Gly 532 | deletion |
| - | Ser 533 | deletion |
| - | Thr 534 | deletion |
| - | Ala 535 | deletion |
| - | Gln 536 | deletion |
| - | Val 537 | deletion |
| - | Pro 538 | deletion |
| - | Ala 539 | deletion |
| - | Pro 540 | deletion |
| - | Thr 541 | deletion |
| - | Ala 542 | deletion |
| - | Ser 543 | deletion |
| - | Pro 544 | deletion |
| - | Pro 545 | deletion |
| - | Pro 546 | deletion |
| - | Glu 547 | deletion |
| - | Gly 548 | deletion |
| - | Pro 549 | deletion |
| - | Val 550 | deletion |
| - | Leu 551 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109534.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1358.9 | |
| All* | Total formula weight | 110893.2 |
