7UIR
Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP
Replaces: 6XF0Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Calcium/calmodulin-dependent protein kinase type II subunit alpha | polymer | 268 | 30548.1 | 2 | UniProt (Q9UQM7) Pfam (PF00069) | Homo sapiens (human) | CaMK-II subunit alpha |
| 2 | C, D (C, D) | T-lymphoma invasion and metastasis-inducing protein 1 | polymer | 19 | 2160.5 | 2 | UniProt (Q60610) | Mus musculus | TIAM-1 |
| 3 | E (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | F, H (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, B: 7 - 274 (UniProt: Q9UQM7)
| PDB | External Database | Details |
|---|---|---|
| Asn 135 | Asp 135 | engineered mutation |
| Lys 223 | Gln 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65417.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1301.3 | |
| All* | Total formula weight | 66718.5 |
