7UGG

Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 3	polymer	808	92573.6	4	UniProt (Q8K424) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB	Mus musculus (house mouse)	TrpV3
2	D, A, B, C	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	24	Chemie (POV)
3	D, A, B	Dyclonine	non-polymer		289.4	4	Chemie (N8R)
4	D, A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5		water	water		18.0	124	Chemie (HOH)

Sequence modifications

A, B, C, D: 3 - 791 (UniProt: Q8K424)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Leu 792	-	expression tag
Val 793	-	expression tag
Pro 794	-	expression tag
Arg 795	-	expression tag
Gly 796	-	expression tag
Ser 797	-	expression tag
Ala 798	-	expression tag
Ala 799	-	expression tag
Ala 800	-	expression tag
Trp 801	-	expression tag
Ser 802	-	expression tag
His 803	-	expression tag
Pro 804	-	expression tag
Gln 805	-	expression tag
Phe 806	-	expression tag
Glu 807	-	expression tag
Lys 808	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	370294.6
Non-Polymers*	Number of molecules	30
	Total formula weight	19445.5
All*	Total formula weight	389740.0

*Water molecules are not included.