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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7UD5

Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, E
(A, E)		Histone H3polymer13615383.02UniProt (A0A310TTQ1)
Pfam (PF00125)
UniProt (by SIFTS) (P84233)		Xenopus laevis (African clawed frog)
2B, F
(B, F)		Histone H4polymer10311394.42UniProt (P62799)
Pfam (PF15511)		Xenopus laevis (African clawed frog)
3C, G
(C, G)		Histone H2Apolymer13014109.42UniProt (Q6AZJ8)
Pfam (PF00125)
Pfam (PF16211)
UniProt (by SIFTS) (P06897)		Xenopus laevis (African clawed frog)
4D, H
(D, H)		Histone H2B 1.1polymer12313629.92UniProt (P02281)
Pfam (PF00125)		Xenopus laevis (African clawed frog)H2B1.1
5I
(I)		601 DNA (146-MER)polymer14644825.61synthetic construct
6J
(J)		601 DNA (146-MER)polymer14645305.91synthetic construct
7K
(K)		cDNA FLJ56846, highly similar to Zinc finger protein HRXpolymer22626247.01UniProt (B4DIJ7)Homo sapiens (human)
8L
(L)		WD repeat-containing protein 5polymer33536648.41UniProt (P61964)
Pfam (PF25175)		Homo sapiens (human)BMP2-induced 3-kb gene protein
9M
(M)		Set1/Ash2 histone methyltransferase complex subunit ASH2polymer53460288.81UniProt (Q9UBL3)
Pfam (PF21257)
Pfam (PF21198)
Pfam (PF00622)		Homo sapiens (human)ASH2-like protein
10N
(N)		Retinoblastoma-binding protein 5polymer53859223.51UniProt (Q15291)
Pfam (PF00400)		Homo sapiens (human)RBBP-5,Retinoblastoma-binding protein RBQ-3
11O
(O)		Polyubiquitin-Bpolymer819164.51UniProt (J3QS39)
Pfam (PF00240)
UniProt (by SIFTS) (P0CG47)		Homo sapiens (human)
12P, Q
(P, Q)		Protein dpy-30 homologpolymer10411733.22UniProt (Q9C005)
Pfam (PF05186)		Homo sapiens (human)Dpy-30-like protein,Dpy-30L
13R
(K)		S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
PubChem (16760024)
PubChem (193)
PubChem (25210495)
PubChem (13792)
PubChem (177678424)
PubChem (44361184)
PubChem (21125603)
PubChem (46936206)
PubChem (50989525)
PubChem (25203782)
PubChem (51380914)
PubChem (52224398)
PubChem (189149)
PubChem (57544532)
PubChem (439155)
PubChem (59046843)
PubChem (59170628)
PubChem (59576228)
PubChem (66805708)
PubChem (70689219)
PubChem (70702054)
PubChem (70832431)
PubChem (52224400)
PubChem (5284331)
PubChem (6419189)
PubChem (118374891)
PubChem (118560068)
PubChem (71170554)
PubChem (13231890)
PubChem (164157219)
PubChem (126969526)
PubChem (129105892)
PubChem (143518505)
PubChem (154578335)
PubChem (163054214)
PubChem (163335525)
14S
(K)		ZINC IONnon-polymer65.41Chemie (ZN)
Sequence modifications
A, E: 0 - 135 (UniProt: A0A310TTQ1)
PDBExternal DatabaseDetails
Nle 4Lys 5engineered mutation
Nle 90Met 91engineered mutation
Nle 120Met 121engineered mutation
D, H: 1 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Met 0-expression tag
Thr 29Ser 33engineered mutation
Cys 117Lys 121engineered mutation
K: 3745 - 3969 (UniProt: B4DIJ7)
PDBExternal DatabaseDetails
Met 3744-initiating methionine
L: 2 - 334 (UniProt: P61964)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ser 1-expression tag
O: 1 - 76 (UniProt: J3QS39)
PDBExternal DatabaseDetails
Gln -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
Met 0-expression tag
Cys 76Gly 76engineered mutation
P, Q: 1 - 99 (UniProt: Q9C005)
PDBExternal DatabaseDetails
Gly -4-expression tag
Ala -3-expression tag
Met -2-expression tag
Asp -1-expression tag
Pro 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains17
Total formula weight414203.6
Non-Polymers*Number of molecules2
Total formula weight449.8
All*Total formula weight414653.4
*Water molecules are not included.

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PDB entries from 2026-05-06

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