7UCK
80S translation initiation complex with ac4c(-1) mRNA and Harringtonine
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 2 | P-site tRNA | polymer | 76 | 24721.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 2 | 1 | mRNA | polymer | 6 | 1957.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 3 | 5 | 28s rRNA | polymer | 3546 | 1150751.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 4 | 7 | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (X06789.1) | Oryctolagus cuniculus (rabbit) | |
| 5 | 8 | 5.8S rRNA | polymer | 156 | 49540.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 6 | 9 | 18S rRNA | polymer | 1698 | 548640.1 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 7 | A | 60S ribosomal protein L8 | polymer | 248 | 26998.6 | 1 | UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947) In PDB | Oryctolagus cuniculus (rabbit) | |
| 8 | B | 60S ribosomal protein L3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) In PDB | Oryctolagus cuniculus (rabbit) | |
| 9 | C | 60S ribosomal protein L4 | polymer | 360 | 40912.3 | 1 | UniProt (A0A5F9DCT1) Pfam (PF14374) Pfam (PF00573) In PDB | Oryctolagus cuniculus (rabbit) | |
| 10 | D | Ribosomal_L18_c domain-containing protein | polymer | 291 | 33935.2 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) In PDB | Oryctolagus cuniculus (rabbit) | |
| 11 | E | 60S ribosomal protein L6 | polymer | 251 | 28818.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) In PDB | Oryctolagus cuniculus (rabbit) | |
| 12 | F | 60S ribosomal protein L7 | polymer | 225 | 26658.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) In PDB | Oryctolagus cuniculus (rabbit) | |
| 13 | G | 60S ribosomal protein L7a | polymer | 234 | 26766.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 14 | H | 60S ribosomal protein L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) In PDB | Oryctolagus cuniculus (rabbit) | |
| 15 | I | Ribosomal protein L10 | polymer | 213 | 24511.9 | 1 | UniProt (B7NZQ2) Pfam (PF00252) In PDB | Oryctolagus cuniculus (rabbit) | Ribosomal protein L10 (Predicted) |
| 16 | J | 60S ribosomal protein L11 | polymer | 170 | 19399.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) In PDB | Oryctolagus cuniculus (rabbit) | |
| 17 | L | 60S ribosomal protein L13 | polymer | 210 | 24200.5 | 1 | UniProt (G1TPV0) In PDB | Oryctolagus cuniculus (rabbit) | |
| 18 | M | 60S ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (U3KNW6) Pfam (PF01929) UniProt (by SIFTS) (G1SZ12) In PDB | Oryctolagus cuniculus (rabbit) | |
| 19 | N | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) In PDB | Oryctolagus cuniculus (rabbit) | |
| 20 | O | 60S ribosomal protein L13a | polymer | 199 | 23144.9 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 21 | P | 60S ribosomal protein L17 | polymer | 153 | 17758.7 | 1 | UniProt (G1SCJ6) Pfam (PF00237) In PDB | Oryctolagus cuniculus (rabbit) | |
| 22 | Q | 60S ribosomal protein L18 | polymer | 187 | 21568.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 23 | R | 60S ribosomal protein L19 | polymer | 180 | 21613.0 | 1 | UniProt (G1TYL6) Pfam (PF01280) In PDB | Oryctolagus cuniculus (rabbit) | |
| 24 | S | 60S ribosomal protein L18a | polymer | 176 | 20827.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 25 | T | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) In PDB | Oryctolagus cuniculus (rabbit) | |
| 26 | U | 60S ribosomal protein L22 | polymer | 98 | 11367.1 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 27 | V | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) In PDB | Oryctolagus cuniculus (rabbit) | |
| 28 | W | Ribosomal protein L24 | polymer | 121 | 14131.5 | 1 | UniProt (G1SE28) Pfam (PF01246) In PDB | Oryctolagus cuniculus (rabbit) | |
| 29 | X | 60S ribosomal protein L23a | polymer | 118 | 13727.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 30 | Y | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) In PDB | Oryctolagus cuniculus (rabbit) | |
| 31 | Z | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) In PDB | Oryctolagus cuniculus (rabbit) | |
| 32 | a | 60S ribosomal protein L27a | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) In PDB | Oryctolagus cuniculus | |
| 33 | b | 60S ribosomal protein L29 | polymer | 116 | 13401.0 | 1 | UniProt (G1SGR6) Pfam (PF01779) In PDB | Oryctolagus cuniculus (rabbit) | |
| 34 | c | 60S ribosomal protein L30 | polymer | 98 | 10914.8 | 1 | UniProt (G1TDL2) Pfam (PF01248) In PDB | Oryctolagus cuniculus (rabbit) | |
| 35 | d | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) In PDB | Oryctolagus cuniculus (rabbit) | |
| 36 | e | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) In PDB | Oryctolagus cuniculus (rabbit) | |
| 37 | f | 60S ribosomal protein L35a | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) In PDB | Oryctolagus cuniculus (rabbit) | |
| 38 | g | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (G1TXG5) Pfam (PF01199) In PDB | Oryctolagus cuniculus (rabbit) | |
| 39 | h | 60S ribosomal protein L35 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) In PDB | Oryctolagus cuniculus (rabbit) | |
| 40 | i | 60S ribosomal protein L36 | polymer | 102 | 11888.4 | 1 | UniProt (G1TTQ5) Pfam (PF01158) In PDB | Oryctolagus cuniculus (rabbit) | |
| 41 | j | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) In PDB | Oryctolagus cuniculus (rabbit) | |
| 42 | k | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 43 | l | 60S ribosomal protein L39 | polymer | 50 | 6324.6 | 1 | UniProt (G1TTN1) Pfam (PF00832) In PDB | Oryctolagus cuniculus (rabbit) | |
| 44 | m | 60S ribosomal protein L40 | polymer | 51 | 6083.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 45 | n | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) In PDB | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
| 46 | o | 60S ribosomal protein L36a | polymer | 103 | 12070.5 | 1 | UniProt (G1T040) Pfam (PF00935) In PDB | Oryctolagus cuniculus (rabbit) | |
| 47 | p | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) In PDB | Oryctolagus cuniculus (rabbit) | |
| 48 | r | 60S ribosomal protein L28 | polymer | 124 | 14220.7 | 1 | UniProt (G1U7L1) Pfam (PF01778) In PDB | Oryctolagus cuniculus (rabbit) | |
| 49 | AA | 40S_SA_C domain-containing protein | polymer | 217 | 24361.9 | 1 | UniProt (G1TJH8) Pfam (PF00318) In PDB | Oryctolagus cuniculus (rabbit) | |
| 50 | BB | 40S ribosomal protein S3a | polymer | 213 | 24759.1 | 1 | UniProt (G1SS70) Pfam (PF01015) In PDB | Oryctolagus cuniculus (rabbit) | |
| 51 | CC | 40S ribosomal protein S2 | polymer | 221 | 24441.8 | 1 | UniProt (G1TUT9) In PDB | Oryctolagus cuniculus (rabbit) | |
| 52 | DD | 40S ribosomal protein S3 | polymer | 228 | 25215.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) In PDB | Oryctolagus cuniculus (rabbit) | |
| 53 | EE | 40S ribosomal protein S4 | polymer | 262 | 29523.7 | 1 | UniProt (G1TA47) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) In PDB | Oryctolagus cuniculus (rabbit) | |
| 54 | FF | Ribosomal protein S5 | polymer | 191 | 21525.9 | 1 | UniProt (G1TFM5) Pfam (PF00177) In PDB | Oryctolagus cuniculus (rabbit) | |
| 55 | GG | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (G1TM55) Pfam (PF01092) In PDB | Oryctolagus cuniculus (rabbit) | |
| 56 | HH | 40S ribosomal protein S7 | polymer | 189 | 21629.3 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 57 | II | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) In PDB | Oryctolagus cuniculus (rabbit) | |
| 58 | JJ | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) In PDB | Oryctolagus cuniculus (rabbit) | |
| 59 | KK | 40S ribosomal protein S10 | polymer | 96 | 11529.7 | 1 | UniProt (G1TPV3) Pfam (PF03501) In PDB | Oryctolagus cuniculus (rabbit) | |
| 60 | LL | 40S ribosomal protein S11 | polymer | 151 | 17586.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) In PDB | Oryctolagus cuniculus (rabbit) | |
| 61 | NN | 40S ribosomal protein S13 | polymer | 149 | 17057.1 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) In PDB | Oryctolagus cuniculus (rabbit) | |
| 62 | OO | 40S ribosomal protein S14 | polymer | 136 | 14544.7 | 1 | UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0) In PDB | Oryctolagus cuniculus (rabbit) | |
| 63 | PP | 40S ribosomal protein S15 | polymer | 120 | 14246.9 | 1 | UniProt (G1U0Q2) Pfam (PF00203) In PDB | Oryctolagus cuniculus (rabbit) | |
| 64 | 40S ribosomal protein S16 | polymer | 142 | 16032.8 | 1 | Oryctolagus cuniculus (rabbit) | |||
| 65 | RR | 40S ribosomal protein S17 | polymer | 132 | 15250.7 | 1 | UniProt (G1TU13) Pfam (PF00833) In PDB | Oryctolagus cuniculus (rabbit) | |
| 66 | SS | 40S ribosomal protein S18 | polymer | 144 | 16898.6 | 1 | UniProt (G1TPG3) Pfam (PF00416) In PDB | Oryctolagus cuniculus (rabbit) | |
| 67 | TT | 40S ribosomal protein S19 | polymer | 141 | 15611.0 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 68 | UU | 40S ribosomal protein S20 | polymer | 100 | 11395.5 | 1 | UniProt (G1SIZ2) Pfam (PF00338) In PDB | Oryctolagus cuniculus (rabbit) | |
| 69 | VV | eS21 | polymer | 83 | 9124.4 | 1 | UniProt (G1TM82) Pfam (PF01249) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
| 70 | WW | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (G1TG89) Pfam (PF00410) In PDB | Oryctolagus cuniculus (rabbit) | |
| 71 | XX | 40S ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) In PDB | Oryctolagus cuniculus (rabbit) | |
| 72 | YY | 40S ribosomal protein S24 | polymer | 124 | 14432.1 | 1 | UniProt (G1T3D8) Pfam (PF01282) In PDB | Oryctolagus cuniculus (rabbit) | |
| 73 | ZZ | 40S ribosomal protein S25 | polymer | 75 | 8526.1 | 1 | UniProt (G1TDB3) Pfam (PF03297) In PDB | Oryctolagus cuniculus (rabbit) | |
| 74 | Aa | eS26 | polymer | 101 | 11645.8 | 1 | UniProt (G1TFE8) Pfam (PF01283) In PDB | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S26 |
| 75 | Bb | 40S ribosomal protein S27 | polymer | 83 | 9349.0 | 1 | UniProt (G1TZ76) Pfam (PF01667) In PDB | Oryctolagus cuniculus (rabbit) | |
| 76 | Cc | 40S ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) In PDB | Oryctolagus cuniculus (rabbit) | |
| 77 | Dd | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (G1U7M4) Pfam (PF00253) In PDB | Oryctolagus cuniculus (rabbit) | |
| 78 | Ee | 40S ribosomal protein S30 | polymer | 55 | 6317.5 | 1 | UniProt (G1T8A2) Pfam (PF04758) In PDB | Oryctolagus cuniculus (rabbit) | |
| 79 | Gg | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) In PDB | Oryctolagus cuniculus (rabbit) | |
| 80 | 5, 8, 9, A, I... | MAGNESIUM ION | non-polymer | 24.3 | 297 | Chemie (MG) | |||
| 81 | 5 | Harringtonine | non-polymer | 531.6 | 1 | Chemie (MQ6) | |||
| 82 | g, j, m, o, p... | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) |
Sequence modifications
7: 1 - 120 (GenBank: X06789.1)
L: 2 - 211 (UniProt: G1TPV0)
R: 2 - 181 (UniProt: G1TYL6)
CC: 58 - 278 (UniProt: G1TUT9)
II: 2 - 207 (UniProt: G1TJW1)
VV: 1 - 83 (UniProt: G1TM82)
Aa: 2 - 102 (UniProt: G1TFE8)
| PDB | External Database | Details |
|---|---|---|
| U 2 | N 2 | conflict |
| C 36 | N 36 | conflict |
| U 102 | N 102 | conflict |
| U 112 | N 112 | conflict |
| U 114 | N 114 | conflict |
| U 119 | C 119 | conflict |
| U 120 | N 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 46 | - | insertion |
| Ala 47 | - | insertion |
| Pro 48 | - | insertion |
| Arg 49 | - | insertion |
| Pro 50 | - | insertion |
| Ala 51 | - | insertion |
| Ala 52 | - | insertion |
| Gly 53 | - | insertion |
| Pro 54 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 38 | His 38 | conflict |
| Arg 151 | His 151 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 73 | Val 50 | conflict |
| Ser 101 | Ala 78 | conflict |
| Gly 119 | Ala 96 | conflict |
| Arg 194 | His 171 | conflict |
| Met 215 | Leu 192 | conflict |
| Arg 227 | Trp 204 | conflict |
| Gly 228 | Ser 205 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Ser 3 | conflict |
| Asp 4 | Asn 4 | conflict |
| Gln 33 | Pro 33 | conflict |
| Phe 50 | Ser 50 | conflict |
| Ala 75 | Ser 75 | conflict |
| Asp 76 | His 76 | conflict |
| Lys 81 | Gln 81 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 28 | Cys 28 | conflict |
| Ala 56 | Val 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 79 |
| Total formula weight | 3105228.4 | |
| Non-Polymers* | Number of molecules | 305 |
| Total formula weight | 8208.0 | |
| All* | Total formula weight | 3113436.4 |
