7UA4
Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (E, F, G, H) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 108 | 11798.5 | 4 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 2 | E, F, G, H (I, J, K, L) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I, J, K, L (A, B, C, D) | Ryanodine receptor 2 | polymer | 4967 | 565216.0 | 4 | UniProt (Q92736) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) | Homo sapiens (human) | RYR-2,RyR2,hRYR-2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor |
| 4 | BA, M, R, W (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | AA, CA, FA, N, Q... (C, D, A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (ATP) | |||
| 6 | DA, O, T, Y (D, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | EA, P, U, Z (D, A, B, C) | XANTHINE | non-polymer | 152.1 | 4 | Chemie (XAN) | |||
| 8 | GA, HA, IA, JA (A, B, C, D) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 4967 (UniProt: Q92736)
| PDB | External Database | Details |
|---|---|---|
| Ser 2474 | Arg 2474 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 2375468.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5087.8 | |
| All* | Total formula weight | 2380556.0 |
