7U69
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Phenethyl Piperidine-4-acrylhydroxamic Acid Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polyamine deacetylase HDAC10 | polymer | 676 | 75055.6 | 1 | UniProt (F1QCV2) Pfam (PF00850) | Danio rerio (zebrafish) | Histone deacetylase 10 |
| 2 | B (A) | (2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide | non-polymer | 274.4 | 1 | Chemie (LS6) | |||
| 3 | C, D (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F, G, H (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | I (A) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A: 2 - 675 (UniProt: F1QCV2)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
| Glu 24 | Ala 24 | conflict |
| Ala 94 | Asp 94 | conflict |
| Phe 154 | Ile 154 | conflict |
| Thr 548 | Ser 548 | conflict |
| Glu 586 | Gly 586 | conflict |
| Arg 593 | Gly 593 | conflict |
| Arg 596 | Thr 596 | conflict |
| Met 613 | Thr 613 | conflict |
| Pro 646 | Leu 646 | conflict |
| Trp 676 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 75055.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 702.9 | |
| All* | Total formula weight | 75758.5 |
