7U4J

Crystal structure of human GPX4-U46C-R152H in complex with TMT10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phospholipid hydroperoxide glutathione peroxidase	polymer	192	21869.1	1	UniProt (P36969) Pfam (PF00255)	Homo sapiens (human)	PHGPx,Glutathione peroxidase 4,GSHPx-4
2	B (A)	~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide	non-polymer		199.6	1	Chemie (8NB)
3	C (A)	THIOCYANATE ION	non-polymer		58.1	1	Chemie (SCN)
4	D (A)	water	water		18.0	159	Chemie (HOH)

Sequence modifications

A: 3 - 170 (UniProt: P36969)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Leu 0	-	expression tag
Glu 1	-	expression tag
Ala 2	-	expression tag
Cys 46	Sec 73	conflict
His 152	Arg 179	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21869.1
Non-Polymers*	Number of molecules	2
	Total formula weight	257.7
All*	Total formula weight	22126.8

*Water molecules are not included.