7U2Z

Crystal structure of human GSK3B in complex with G12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glycogen synthase kinase-3 beta	polymer	348	39532.4	2	UniProt (P49841) Pfam (PF00069)	Homo sapiens (human)	GSK-3 beta,Serine/threonine-protein kinase GSK3B
2	C, E (A, B)	(3R)-1-[3-(2-fluorophenyl)propanoyl]-N-(pyridin-2-yl)pyrrolidine-3-carboxamide	non-polymer		341.4	2	Chemie (L7C)
3	D, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H (A, B)	water	water		18.0	144	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79064.9
Non-Polymers*	Number of molecules	4
	Total formula weight	753.7
All*	Total formula weight	79818.5

*Water molecules are not included.