7U1Q
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43661.8 | 4 | UniProt (P70673) Pfam (PF01007) Pfam (PF17655) | Rattus norvegicus (Norway rat) | BIR,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | E (E) | ATP-binding cassette sub-family C member 8 | polymer | 1582 | 177333.6 | 1 | UniProt (Q09427) Pfam (PF00664) Pfam (PF00005) | Cricetus cricetus (black-bellied hamster) | SUR1, Sulfonylurea receptor 1 |
| 3 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | G, K, N, Q, W (A, B, C, D, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 5 | Chemie (ATP) | |||
| 5 | H (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | CA, I, M, O, R... (E, A, B, C, D) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 6 | Chemie (P5S) | |||
| 7 | J, L, P, S, Y (A, B, C, D, E) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
| 8 | AA, BA, T, X, Z (E) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 5 | Chemie (PTY) | |||
| 9 | V (E) | Repaglinide | non-polymer | 452.6 | 1 | Chemie (BJX) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 351980.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 15250.6 | |
| All* | Total formula weight | 367655.6 |
